Chemistry:Ro48-8684

From HandWiki
Short description: Chemical compound
Ro48-8684
Ro48-8684.svg
Identifiers
PubChem CID
ChemSpider
Chemical and physical data
FormulaC22H26FN5O2
Molar mass411.472 g·mol−1
3D model (JSmol)
  (verify)

Ro48-8684 is a water-soluble benzodiazepine derivative developed by Hoffman-LaRoche in the 1990s, which was designed along with Ro48-6791 as an improved replacement for midazolam, but ultimately proved to have little advantages over the parent drug and has not been introduced into clinical practice.[1][2]

See also

References

  1. "Integrated pharmacokinetics and pharmacodynamics of Ro 48-8684, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects". British Journal of Clinical Pharmacology 44 (5): 487–93. November 1997. doi:10.1046/j.1365-2125.1997.t01-1-00613.x. PMID 9384466. 
  2. "[Pharmacokinetic-pharmacodynamic modeling in phase II of drug development. A comparative study with young and old volunteers with benzdiazepine as an example]". Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie 34 (10): 634–7. October 1999. doi:10.1055/s-1999-213. PMID 10548960.