Chemistry:ORG-21465
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Short description: Chemical compound
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| Other names | 2β-(2,2-Dimethyl-4-morpholinyl)-3α-hydroxy-11,20-dioxo-5α-pregnan-21-yl methanesulfonate |
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| Formula | C27H43NO7S |
| Molar mass | 525.70 g·mol−1 |
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ORG-21465 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive allosteric modulator. It is similar to related drugs such as ORG-20599, and was similarly developed as an improved alternative to other sedative steroids such as althesin and allopregnanolone, which despite its superior properties in some respects has not proved to offer enough advantages to be accepted into clinical use.[1][2]
Chemistry
See also
References
- ↑ "ORG 21465, a new water-soluble steroid hypnotic: more of the same or something different?". British Journal of Anaesthesia 79 (4): 417–9. October 1997. doi:10.1093/bja/79.4.417. PMID 9389254.
- ↑ "Etomidate and other non-barbiturates". Modern Anesthetics. Handbook of Experimental Pharmacology. 182. 2008. pp. 267–82. doi:10.1007/978-3-540-74806-9_13. ISBN 978-3-540-72813-9.
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