Chemistry:CLCA4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene. The protein encoded by this gene is a chloride channel.[1] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[2]
See also
References
- ↑ "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. July 1999. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792.
- ↑ "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels.". Proteins 63 (3): 424–39. 2006. doi:10.1002/prot.20887. PMID 16470849.
Further reading
- "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. 2000. doi:10.1073/pnas.090521697. PMID 10758170. Bibcode: 2000PNAS...97.4832L.
- "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.". Hum. Genet. 115 (6): 483–91. 2004. doi:10.1007/s00439-004-1190-y. PMID 15490240.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Molecular characteristics and functional diversity of CLCA family members.". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. 2000. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307.
External links
- CLCA3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CLCA4 genome location and CLCA4 gene details page in the UCSC Genome Browser.
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