Biology:KCNAB2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene.

Function

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

In melanocytic cells KCNAB2 gene expression may be regulated by MITF.

Interactions

KCNAB2 has been shown to interact with KCNA2.

See also

• Voltage-gated potassium channel

Further reading

• "Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product.". FEBS Lett. 370 (1–2): 32–6. 1995. doi:10.1016/0014-5793(95)00785-8. PMID 7649300. 
• "Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily.". Cell 79 (7): 1133–5. 1995. doi:10.1016/0092-8674(94)90004-3. PMID 8001150. 
• "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits.". J. Biol. Chem. 271 (12): 7084–9. 1996. doi:10.1074/jbc.271.12.7084. PMID 8636142. 
• "Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density.". Circulation 98 (14): 1383–93. 1998. doi:10.1161/01.cir.98.14.1383. PMID 9760292. 
• "Subunit composition of Kv1 channels in human CNS.". J. Neurochem. 73 (2): 849–58. 1999. doi:10.1046/j.1471-4159.1999.0730849.x. PMID 10428084. 
• "Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels.". Neuron 24 (4): 1037–47. 2000. doi:10.1016/S0896-6273(00)81049-1. PMID 10624965. 
• "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.". J. Biol. Chem. 278 (8): 6128–35. 2003. doi:10.1074/jbc.M205162200. PMID 12431995. 
• "A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels.". Science 301 (5633): 646–9. 2003. doi:10.1126/science.1086998. PMID 12893943. Bibcode: 2003Sci...301..646G. 
• "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. 2005. doi:10.1038/nbt1046. PMID 15592455. 
• "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 

External links

• KCNAB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.