Biology:CLIC2

Short description: Protein-coding gene in humans

Generic protein structure example

Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti.

See also

• Chloride channel

Further reading

• "A chloride channel widely expressed in epithelial and non-epithelial cells". Nature 356 (6364): 57–60. 1992. doi:10.1038/356057a0. PMID 1311421. Bibcode: 1992Natur.356...57T. 
• "Transcriptional analysis of the candidate region for incontinentia pigmenti (IP2) in Xq28". Genome Res. 6 (10): 922–34. 1997. doi:10.1101/gr.6.10.922. PMID 8908511. 
• Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters 584 (10): 2112–21. doi:10.1016/j.febslet.2010.03.013. PMID 20226783. 
• "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863. 
• "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. 2001. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex". J. Biol. Chem. 278 (18): 16262–70. 2003. doi:10.1074/jbc.M209828200. PMID 12601004. 
• "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. 540 (1–3): 77–80. 2003. doi:10.1016/S0014-5793(03)00228-X. PMID 12681486. 
• "CLIC-2 modulates cardiac ryanodine receptor Ca²⁺ release channels". Int. J. Biochem. Cell Biol. 36 (8): 1599–612. 2005. doi:10.1016/j.biocel.2004.01.026. PMID 15147738. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336. 
• "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R. 
• "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics 5 (15): 3876–84. 2006. doi:10.1002/pmic.200401239. PMID 16130169. 
• "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. 2006. doi:10.1093/nar/gkj139. PMID 16381901. 

External links

• CLIC2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CLIC2 genome location and CLIC2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.