Biology:CLCNKB
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.[1][2]
Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels.[3] Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome.[4] CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.[1]
See also
- Chloride channel
- BSND, barttin, accessory subunit beta for this channel
References
- ↑ 1.0 1.1 "Entrez Gene: CLCNKB chloride channel Kb". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1188.
- ↑ "Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization". Genomics 36 (2): 372–4. September 1996. doi:10.1006/geno.1996.0479. PMID 8812470.
- ↑ "Chloride channels: an emerging molecular picture". BioEssays 19 (2): 117–26. February 1997. doi:10.1002/bies.950190206. PMID 9046241.
- ↑ "Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance". Nat Clin Pract Nephrol 4 (1): 38–46. January 2008. doi:10.1038/ncpneph0689. PMID 18094726.
Further reading
- "Two highly homologous members of the ClC chloride channel family in both rat and human kidney". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 6943–7. 1994. doi:10.1073/pnas.91.15.6943. PMID 8041726. Bibcode: 1994PNAS...91.6943K.
- "Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney". Kidney Int. 48 (5): 1497–503. 1996. doi:10.1038/ki.1995.439. PMID 8544406.
- "Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization". Genomics 36 (2): 372–4. 1997. doi:10.1006/geno.1996.0479. PMID 8812470.
- "Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III". Nat. Genet. 17 (2): 171–8. 1997. doi:10.1038/ng1097-171. PMID 9326936.
- "Mutations in the chloride channel gene CLCNKB as a cause of classic Bartter syndrome". J. Am. Soc. Nephrol. 11 (8): 1449–59. 2000. doi:10.1681/ASN.V1181449. PMID 10906158.
- "Mutations in the chloride channel gene, CLCNKB, leading to a mixed Bartter-Gitelman phenotype". Pediatr. Res. 48 (6): 754–8. 2001. doi:10.1203/00006450-200012000-00009. PMID 11102542.
- "Barttin is a Cl− channel beta-subunit crucial for renal Cl− reabsorption and inner ear K+ secretion". Nature 414 (6863): 558–61. 2002. doi:10.1038/35107099. PMID 11734858. Bibcode: 2001Natur.414..558E.
- "Bartter syndrome type 3: an unusual cause of nephrolithiasis". Nephrol. Dial. Transplant. 17 (3): 521–3. 2002. doi:10.1093/ndt/17.3.521. PMID 11865110.
- "A novel mutation in the chloride channel gene, CLCNKB, as a cause of Gitelman and Bartter syndromes". Kidney Int. 63 (1): 24–32. 2004. doi:10.1046/j.1523-1755.2003.00730.x. PMID 12472765.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Expression of CLC-KB gene promoter in the mouse cochlea". NeuroReport 14 (12): 1571–3. 2003. doi:10.1097/00001756-200308260-00006. PMID 14502078.
- "A common sequence variation of the CLCNKB gene strongly activates ClC-Kb chloride channel activity". Kidney Int. 65 (1): 190–7. 2004. doi:10.1111/j.1523-1755.2004.00363.x. PMID 14675050.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Salt wasting and deafness resulting from mutations in two chloride channels". N. Engl. J. Med. 350 (13): 1314–9. 2004. doi:10.1056/NEJMoa032843. PMID 15044642.
- "Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension". Hypertension 43 (6): 1175–81. 2004. doi:10.1161/01.HYP.0000129824.12959.f0. PMID 15148291.
- "Novel mutations of the chloride channel Kb gene in two Japanese patients clinically diagnosed as Bartter syndrome with hypocalciuria". J. Clin. Endocrinol. Metab. 89 (11): 5847–50. 2004. doi:10.1210/jc.2004-0775. PMID 15531551.
- "No association with hypertension of CLCNKB and TNFRSF1B polymorphisms at a hypertension locus on chromosome 1p36". J. Hypertens. 23 (8): 1491–6. 2005. doi:10.1097/01.hjh.0000174300.73992.cc. PMID 16003175.
- "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "A Spanish founder mutation in the chloride channel gene, CLCNKB, as a cause of atypical Bartter syndrome in adult age". Horm. Res. 65 (2): 62–8. 2006. doi:10.1159/000090601. PMID 16391491.
- "Barttin modulates trafficking and function of ClC-K channels". Proc. Natl. Acad. Sci. U.S.A. 103 (30): 11411–6. 2006. doi:10.1073/pnas.0601631103. PMID 16849430. Bibcode: 2006PNAS..10311411S.
External links
- CLCNKB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CLCNKB genome location and CLCNKB gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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