Biology:HCN2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene.[1][2][3][4]
Interactions
HCN2 has been shown to interact with HCN1[5][6] and HCN4.[5]
Function
The function of the channel is not known although its activation by hyperpolarization alludes to the funny channels in the sinoatrial node of the heart (which form the basis of spontaneous generation of electrical rhythm). These channels have recently been associated with chronic pain and blocking the gene is associated with resolution of neuropathic episodes of pain.[7]
See also
- Cyclic nucleotide-gated ion channel
References
- ↑ "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America 94 (26): 14815–20. Dec 1997. doi:10.1073/pnas.94.26.14815. PMID 9405696. Bibcode: 1997PNAS...9414815S.
- ↑ "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell 93 (5): 717–29. May 1998. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217.
- ↑ "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews 57 (4): 455–62. Dec 2005. doi:10.1124/pr.57.4.8. PMID 16382102.
- ↑ "Entrez Gene: HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=610.
- ↑ 5.0 5.1 "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". The Journal of Biological Chemistry 278 (44): 43781–6. Oct 2003. doi:10.1074/jbc.M306958200. PMID 12928435.
- ↑ "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". The Journal of Biological Chemistry 277 (33): 29634–42. Aug 2002. doi:10.1074/jbc.M200504200. PMID 12034718.
- ↑ "Gene find may lead to pills that kill chronic pain". The Times of India. 10 September 2011. http://articles.timesofindia.indiatimes.com/2011-09-10/science/30138741_1_chronic-pain-neuropathic-pain-gene.
Further reading
- "CCG repeats in cDNAs from human brain". Human Genetics 103 (6): 666–73. Dec 1998. doi:10.1007/s004390050889. PMID 9921901.
- "Two pacemaker channels from human heart with profoundly different activation kinetics". The EMBO Journal 18 (9): 2323–9. May 1999. doi:10.1093/emboj/18.9.2323. PMID 10228147.
- "The human gene coding for HCN2, a pacemaker channel of the heart". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1446 (3): 419–25. Sep 1999. doi:10.1016/s0167-4781(99)00092-5. PMID 10524219.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. Nov 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Functional heteromerization of HCN1 and HCN2 pacemaker channels". The Journal of Biological Chemistry 276 (9): 6069–72. Mar 2001. doi:10.1074/jbc.C000738200. PMID 11133998.
- "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". The Journal of Biological Chemistry 277 (33): 29634–42. Aug 2002. doi:10.1074/jbc.M200504200. PMID 12034718.
- "Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells". Pflügers Archiv 444 (5): 597–601. Aug 2002. doi:10.1007/s00424-002-0860-7. PMID 12194012.
- "Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel". Nature Neuroscience 6 (4): 353–61. Apr 2003. doi:10.1038/nn1028. PMID 12640457. https://escholarship.org/uc/item/5wh969wf.
- "Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4". The Journal of Biological Chemistry 278 (36): 33672–80. Sep 2003. doi:10.1074/jbc.M305318200. PMID 12813043.
- "Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus". The Journal of Neuroscience 23 (17): 6826–36. Jul 2003. doi:10.1523/JNEUROSCI.23-17-06826.2003. PMID 12890777.
- "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". The Journal of Biological Chemistry 278 (44): 43781–6. Oct 2003. doi:10.1074/jbc.M306958200. PMID 12928435.
- "Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias". Circulation 111 (4): 399–404. Feb 2005. doi:10.1161/01.CIR.0000153799.65783.3A. PMID 15687126.
- "Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization". Journal of Cell Science 118 (Pt 13): 2803–12. Jul 2005. doi:10.1242/jcs.02423. PMID 15961404.
- "Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels". Biophysical Journal 89 (3): 2159–69. Sep 2005. doi:10.1529/biophysj.105.063792. PMID 15980171. Bibcode: 2005BpJ....89.2159C.
External links
- HCN2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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