Chemistry:Pritumumab
From HandWiki
Short description: Monoclonal antibody
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | vimentin |
| Clinical data | |
| ATC code |
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| Identifiers | |
| CAS Number | |
| ChemSpider |
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| UNII | |
| Chemical and physical data | |
| Formula | C6440H9968N1708O2016S42 |
| Molar mass | 144923.04 g·mol−1 |
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Pritumumab (PTB) is a human monoclonal antibody targeted against glioma.[1] It works by binding to the ecto-domain of vimentin on the surface of cancer cells.[1][2] developed by Nascent Biotech.
It is in clinical trials for the treatment of glioma.[3][4] The FDA granted orphan drug designation in 2015.
The target of Pritumumab, cell surface vimentin, has been implicated in the replication of coronavirus, specifically in Severe acute respiratory syndrome coronavirus (SARS-CoV).[5]
PTB has been proposed as a potential treatment for COVID-19 and related Viral Infections.[6]
References
- ↑ 1.0 1.1 "Pritumumab, the first therapeutic antibody for glioma patients". Human Antibodies 26 (2): 95–101. February 2018. doi:10.3233/HAB-170326. PMID 29036806.
- ↑ "International Nonproprietary Names for Pharmaceutical Substances (INN)". WHO Drug Information 18 (1). 2004. http://whqlibdoc.who.int/druginfo/INN_2004_list51.pdf.
- ↑ "Nascent Biologics Proven Cancer Cure Back in the Hands Of U.S. Inventor After 27 Years In Japan". Nascent Biologics. 1 October 2009. http://www.nascentbiologics.com/news/science/70-proven-cancer-cure-back-in-the-hands-of-us-inventor-after-27-years-in-japan.
- ↑ Clinical trial number NCT04396717 for "Safety Study of Pritumumab in Brain Cancer" at ClinicalTrials.gov
- ↑ "Surface vimentin is critical for the cell entry of SARS-CoV". Journal of Biomedical Science 23: 14. January 2016. doi:10.1186/s12929-016-0234-7. PMID 26801988.
- ↑ "Race For Vaccine Intensifies As COVID-19 Second Wave of Outbreaks Threatens". Financialnewsmedia.com. 17 June 2020. https://www.prnewswire.com/news-releases/race-for-vaccine-intensifies-as-covid-19-second-wave-of-outbreaks-threatens-301078296.html.
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