Chemistry:Ficlatuzumab

From HandWiki
Short description: Monoclonal antibody
Ficlatuzumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized (from mouse)
TargetHGF
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6446H9954N1718O2026S46
Molar mass145409.30 g·mol−1
 ☒N☑Y (what is this?)  (verify)

Ficlatuzumab is a humanized monoclonal antibody designed for the treatment of cancers.[1]

It is a humanized monoclonal antibody that binds to hepatocyte growth factor, thus inhibiting the c-MET receptor signaling cascade.[2]

Ficlatuzumab was developed by AVEO Pharmaceuticals. In May 2012, AVEO released results of a Phase II clinical trial comparing gefitinib alone and in combination with ficlatuzamab in treatment-naive Asian patients with non-small cell lung cancer.[3]

References

  1. "Statement On A Nonproprietary Name Adopted By The USAN Council: Ficlatuzumab". American Medical Association. http://www.ama-assn.org/resources/doc/usan/ficlatuzumab.pdf. 
  2. "A Review of Monoclonal Antibody-Based Treatments in Non-small Cell Lung Cancer". Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology. 1286. 2021. pp. 49–64 (57). doi:10.1007/978-3-030-55035-6_3. ISBN 978-3-030-55034-9. 
  3. "AVEO Releases Phase 2 Data", Drug Discovery & Development: dddmag.com, May 3, 2012, http://www.dddmag.com/news/2012/05/aveo-releases-phase-2-data, retrieved June 3, 2012