Biology:SIRPB1
 Generic protein structure example |
Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.[1][2][3] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.[3]
Interactions
SIRPB1 has been shown to interact with TYROBP.[4][5]
References
- ↑ Kharitonenkov A; Chen Z; Sures I; Wang H; Schilling J; Ullrich A (April 1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature 386 (6621): 181–6. doi:10.1038/386181a0. PMID 9062191. Bibcode: 1997Natur.386..181K.
- ↑ van den Berg TK; van Beek EM; Buhring HJ; Colonna M; Hamaguchi M; Howard CJ; Kasuga M; Liu Y et al. (December 2005). "A nomenclature for signal regulatory protein family members". J Immunol 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511.
- ↑ 3.0 3.1 "Entrez Gene: SIRPB1 signal-regulatory protein beta 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10326.
- ↑ Dietrich, J; Cella M; Seiffert M; Bühring H J; Colonna M (January 2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. (UNITED STATES) 164 (1): 9–12. doi:10.4049/jimmunol.164.1.9. ISSN 0022-1767. PMID 10604985.
- ↑ Tomasello, E; Cant C; Bühring H J; Vély F; André P; Seiffert M; Ullrich A; Vivier E (August 2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. (GERMANY) 30 (8): 2147–56. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. ISSN 0014-2980. PMID 10940905.
Further reading
- "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells.". J. Immunol. 164 (1): 9–12. 2000. doi:10.4049/jimmunol.164.1.9. PMID 10604985.
- "Association of signal-regulatory proteins beta with KARAP/DAP-12.". Eur. J. Immunol. 30 (8): 2147–56. 2000. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. PMID 10940905.
- "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- Cannon JP; Haire RN; Litman GW (2002). "Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate.". Nat. Immunol. 3 (12): 1200–7. doi:10.1038/ni849. PMID 12415263.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration". J. Biol. Chem. 280 (43): 36132–40. 2006. doi:10.1074/jbc.M506419200. PMID 16081415.
- "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. 2006. doi:10.1021/pr0502065. PMID 16335952.
- "SIRPB1 copy-number polymorphism as candidate quantitative trait locus for impulsive-disinhibited personality". Genes, Brain and Behavior 13 (7): 653–62. September 2014. doi:10.1111/gbb.12154. PMID 25039969.
External links
- SIRPB1 human gene location in the UCSC Genome Browser.
- SIRPB1 human gene details in the UCSC Genome Browser.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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