Biology:ATP1B3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. ATP1B3 has also been designated as CD298 (cluster of differentiation 298).

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.

Further reading

• "Molecular genetics of Na,K-ATPase". Prog. Nucleic Acid Res. Mol. Biol.. Progress in Nucleic Acid Research and Molecular Biology 38: 37–89. 1990. doi:10.1016/S0079-6603(08)60708-4. ISBN 978-0-12-540038-1. PMID 2158121. 
• Jørgensen PL (1982). "Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+ +K+)-ATPase". Biochim. Biophys. Acta 694 (1): 27–68. doi:10.1016/0304-4157(82)90013-2. PMID 6289898. 
• "Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation". Int. Immunol. 14 (12): 1407–14. 2003. doi:10.1093/intimm/dxf112. PMID 12456588. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. 2003. doi:10.1038/nbt827. PMID 12754519. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. 2007. doi:10.1021/pr060363j. PMID 17081065. 
• "Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells". Tissue Antigens 68 (6): 509–17. 2007. doi:10.1111/j.1399-0039.2006.00726.x. PMID 17176442. 
• "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931. 
• "Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes". J. Appl. Physiol. 103 (1): 39–47. 2007. doi:10.1152/japplphysiol.00236.2006. PMID 17446412. 

External links

• ATP1B3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human ATP1B3 genome location and ATP1B3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.