Biology:FOSL2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

See also

• AP-1 (transcription factor)

Further reading

• "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene 5 (3): 249–55. March 1990. PMID 2107490. 
• "Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23". Genomics 38 (1): 72–5. November 1996. doi:10.1006/geno.1996.0593. PMID 8954781. 
• "Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells". Blood 94 (3): 959–67. August 1999. doi:10.1182/blood.V94.3.959.415k20_959_967. PMID 10419887. 
• "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors". Journal of Neuroimmunology 105 (1): 78–90. June 2000. doi:10.1016/S0165-5728(00)00195-8. PMID 10713367. 
• "Requirement of an AP-1 site in the calcium response region of the involucrin promoter". The Journal of Biological Chemistry 275 (31): 24080–8. August 2000. doi:10.1074/jbc.M002508200. PMID 10816578. 
• "Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators". Journal of Cancer Research and Clinical Oncology 127 (9): 545–50. September 2001. doi:10.1007/s004320100255. PMID 11570575. 
• "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region". Biochemical and Biophysical Research Communications 289 (1): 25–33. November 2001. doi:10.1006/bbrc.2001.5929. PMID 11708771. 
• "Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter". Molecular and Cellular Biology 22 (13): 4522–34. July 2002. doi:10.1128/MCB.22.13.4522-4534.2002. PMID 12052862. 
• "Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1". Cardiovascular Research 59 (3): 639–48. September 2003. doi:10.1016/S0008-6363(03)00472-3. PMID 14499865. 
• "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. August 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 

External links

• FOSL2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook FOSL2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.