Biology:ATF5
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.[1]
Function
First described by Nishizawa and Nagata,[2] ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.[3][4]
ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.
ATF5 expression is regulated at both the transcriptional and translational level.
ATF5 is expressed in VZ and SVZ during brain development.
The human ATF5 protein is made up of 282 amino acids.
ATF5 is a transcription factor that contains a bZip domain.
See also
Interactions
ATF5 has been shown to interact with DISC1[5] and TRIB3.[6]
References
- ↑ "Entrez Gene: ATF5 activating transcription factor 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22809.
- ↑ "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. July 1999. doi:10.1128/mcb.19.7.5001. PMID 10373550.
- ↑ "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis". Gene 273 (1): 1–11. July 2001. doi:10.1016/S0378-1119(01)00551-0. PMID 11483355.
- ↑ "Classification of human B-ZIP proteins based on dimerization properties". Mol. Cell. Biol. 22 (18): 6321–6335. September 2002. doi:10.1128/MCB.22.18.6321-6335.2002. PMID 12192032.
- ↑ "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–1608. Jul 2003. doi:10.1093/hmg/ddg162. PMID 12812986.
- ↑ "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–948. May 2008. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.
Further reading
- "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. 1999. doi:10.1128/mcb.19.7.5001. PMID 10373550.
- "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–13972. 2001. doi:10.1073/pnas.240452197. PMID 11087824.
- "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J. Biol. Chem. 276 (17): 13718–26. 2001. doi:10.1074/jbc.M011562200. PMID 11278933.
- "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–1608. 2004. doi:10.1093/hmg/ddg162. PMID 12812986.
- "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene 23 (35): 5901–5911. 2004. doi:10.1038/sj.onc.1207782. PMID 15221005.
- "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity". Biochem. Biophys. Res. Commun. 321 (4): 954–960. 2004. doi:10.1016/j.bbrc.2004.07.053. PMID 15358120.
- "The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription". J. Virol. 79 (11): 6932–6939. 2005. doi:10.1128/JVI.79.11.6932-6939.2005. PMID 15890932.
- "Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP". Biol. Chem. 386 (9): 873–879. 2005. doi:10.1515/BC.2005.102. PMID 16164412.
- "Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5". Oncogene 25 (6): 907–916. 2006. doi:10.1038/sj.onc.1209116. PMID 16170340.
- "ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells". Biochem. Biophys. Res. Commun. 339 (2): 591–596. 2006. doi:10.1016/j.bbrc.2005.11.054. PMID 16300731.
- "Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder". Neurosci. Lett. 417 (3): 316–321. 2007. doi:10.1016/j.neulet.2007.02.054. PMID 17346882.
- "Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region". J. Biol. Chem. 283 (5): 2543–2553. 2008. doi:10.1074/jbc.M707781200. PMID 18055463.
External links
- ATF5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human ATF5 genome location and ATF5 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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