Biology:CBFA2T2
 Generic protein structure example |
Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene.[1][2]
Function
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.[2]
Interactions
CBFA2T2 has been shown to interact with RUNX1T1.[3][4][5]
References
- ↑ "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family". Genomics 52 (3): 332–41. December 1998. doi:10.1006/geno.1998.5429. PMID 9790752.
- ↑ 2.0 2.1 "Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9139.
- ↑ "Towards a proteome-scale map of the human protein–protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439–47. December 2003. doi:10.1046/j.0902-4441.2003.00166.x. PMID 14703694.
- ↑ "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies". Oncogene 21 (43): 6703–12. September 2002. doi:10.1038/sj.onc.1205882. PMID 12242670.
Further reading
- "The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.". Mol. Cell. Biol. 18 (2): 846–58. 1998. doi:10.1128/MCB.18.2.846. PMID 9447981.
- "EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias.". Blood 92 (9): 3481–4. 1998. doi:10.1182/blood.V92.9.3481. PMID 9787195.
- "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1.". Gene 241 (2): 287–95. 2000. doi:10.1016/S0378-1119(99)00481-3. PMID 10675041.
- "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies.". Oncogene 21 (43): 6703–12. 2002. doi:10.1038/sj.onc.1205882. PMID 12242670.
- "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins.". Eur. J. Haematol. 71 (6): 439–47. 2004. doi:10.1046/j.0902-4441.2003.00166.x. PMID 14703694.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. 2005. doi:10.1038/nbt971. PMID 15146197.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "E protein silencing by the leukemogenic AML1-ETO fusion protein.". Science 305 (5688): 1286–9. 2004. doi:10.1126/science.1097937. PMID 15333839. Bibcode: 2004Sci...305.1286Z.
- "Towards a proteome-scale map of the human protein–protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "A protein–protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- "ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.". Mol. Cancer Res. 4 (9): 655–65. 2006. doi:10.1158/1541-7786.MCR-05-0249. PMID 16966434.
External links
- CBFA2T2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CBFA2T2 genome location and CBFA2T2 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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