Biology:Brain-specific angiogenesis inhibitor 1
 Generic protein structure example |
Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene.[1][2] It is a member of the adhesion-GPCR family of receptors.[3]
Function
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.[2]
Interactions
Brain-specific angiogenesis inhibitor 1 has been shown to interact with BAIAP3[4] and MAGI1.[5]
References
- ↑ "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenetics and Cell Genetics 79 (1–2): 103–8. Apr 1998. doi:10.1159/000134693. PMID 9533023.
- ↑ 2.0 2.1 "Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=575.
- ↑ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
- ↑ "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications 251 (1): 158–65. Oct 1998. doi:10.1006/bbrc.1998.9408. PMID 9790924.
- ↑ "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications 247 (3): 597–604. Jun 1998. doi:10.1006/bbrc.1998.8603. PMID 9647739.
External links
- Human ADGRB1 genome location and ADGRB1 gene details page in the UCSC Genome Browser.
Further reading
- "Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells". Nature Genetics 8 (2): 171–6. Oct 1994. doi:10.1038/ng1094-171. PMID 7531056.
- "A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis". Oncogene 15 (18): 2145–50. Oct 1997. doi:10.1038/sj.onc.1201542. PMID 9393972.
- "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications 247 (3): 597–604. Jun 1998. doi:10.1006/bbrc.1998.8603. PMID 9647739.
- "Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer". International Journal of Oncology 13 (5): 967–70. Nov 1998. doi:10.3892/ijo.13.5.967. PMID 9772287.
- "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications 251 (1): 158–65. Oct 1998. doi:10.1006/bbrc.1998.9408. PMID 9790924.
- "Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1". Cytogenetics and Cell Genetics 84 (1–2): 75–82. 1999. doi:10.1159/000015219. PMID 10343108.
- "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase". The Journal of Biological Chemistry 275 (28): 21477–85. Jul 2000. doi:10.1074/jbc.M909741199. PMID 10748157.
- "Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein". Brain Research. Molecular Brain Research 87 (2): 223–37. Mar 2001. doi:10.1016/S0169-328X(01)00004-3. PMID 11245925.
- "Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis". British Journal of Cancer 86 (3): 490–6. Feb 2002. doi:10.1038/sj.bjc.6600067. PMID 11875720.
- "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". The Journal of Biological Chemistry 277 (24): 21697–711. Jun 2002. doi:10.1074/jbc.M112339200. PMID 11937501.
- "Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells". Neuroscience Research 43 (1): 69–74. May 2002. doi:10.1016/S0168-0102(02)00018-4. PMID 12074842.
- "Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression". The American Journal of Pathology 162 (1): 19–27. Jan 2003. doi:10.1016/S0002-9440(10)63794-7. PMID 12507886.
- "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Molecular & Cellular Proteomics 1 (12): 947–55. Dec 2002. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
- "Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin". Experimental Cell Research 294 (1): 172–84. Mar 2004. doi:10.1016/j.yexcr.2003.11.008. PMID 14980512.
- "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics 84 (1): 23–33. Jul 2004. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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