Biology:Alpha-1B adrenergic receptor

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

The alpha-1B adrenergic receptor (α_1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. The crystal structure of the α_1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

Ligands

Antagonists

• L-765,314
• Risperidone
• Brexpiprazole

Interactions

Alpha-1B adrenergic receptor has been shown to interact with AP2M1. A role in regulation of dopaminergic neurotransmission has also been suggested.

See also

• Adrenergic receptor

External links

• Human ADRA1B genome location and ADRA1B gene details page in the UCSC Genome Browser.

Further reading

• "Genomic organization and expression of the human alpha 1B-adrenergic receptor.". J. Biol. Chem. 267 (30): 21936–45. 1992. doi:10.1016/S0021-9258(19)36703-1. PMID 1328250. 
• "G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11354–8. 1992. doi:10.1073/pnas.88.24.11354. PMID 1662393. PMC 53133. https://dukespace.lib.duke.edu/dspace/bitstream/10161/7850/1/Allen_G%20protein%20coupled%20receptor%20genes%20as%20protooncogenes_constitutively%20activating%20mutation.pdf. 
• "Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5". J. Biol. Chem. 266 (10): 6365–9. 1991. doi:10.1016/S0021-9258(18)38126-2. PMID 1706716. 
• "Chromosomal organization of adrenergic receptor genes". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516–20. 1990. doi:10.1073/pnas.87.4.1516. PMID 2154750. Bibcode: 1990PNAS...87.1516Y. 
• "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues". J. Pharmacol. Exp. Ther. 272 (1): 134–42. 1995. PMID 7815325. 
• "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem. Biophys. Res. Commun. 201 (3): 1296–304. 1994. doi:10.1006/bbrc.1994.1845. PMID 8024574. 
• "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype". Mol. Pharmacol. 45 (4): 703–8. 1994. PMID 8183249. 
• "Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 271 (9): 5049–58. 1996. doi:10.1074/jbc.271.9.5049. PMID 8617782. 
• "Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 272 (45): 28712–9. 1997. doi:10.1074/jbc.272.45.28712. PMID 9353340. 
• "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11)". Cell. Signal. 10 (2): 101–5. 1998. doi:10.1016/S0898-6568(97)00097-1. PMID 9481484. 
• "Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells". Biochem. Biophys. Res. Commun. 268 (1): 25–30. 2000. doi:10.1006/bbrc.1999.2066. PMID 10652206. 
• "Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes". J. Neurochem. 74 (6): 2392–400. 2000. doi:10.1046/j.1471-4159.2000.0742392.x. PMID 10820200. 
• "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1". J. Biol. Chem. 278 (1): 672–8. 2003. doi:10.1074/jbc.M201375200. PMID 12409310. 
• "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. 2003. doi:10.1074/jbc.M302110200. PMID 12644451. 
• "Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130". Mol. Pharmacol. 63 (5): 1104–16. 2003. doi:10.1124/mol.63.5.1104. PMID 12695539. 
• "Specific interactions between gC1qR and alpha1-adrenoceptor subtypes". J. Recept. Signal Transduct. Res. 23 (2–3): 185–95. 2004. doi:10.1081/RRS-120025200. PMID 14626446. 
• "Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors". J. Biol. Chem. 279 (15): 15541–9. 2004. doi:10.1074/jbc.M314014200. PMID 14736874. 
• "Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits". J. Biol. Chem. 279 (35): 36593–600. 2004. doi:10.1074/jbc.M402084200. PMID 15220331. 
• "Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes". Endocrinology 145 (11): 5157–67. 2004. doi:10.1210/en.2004-0728. PMID 15297446. 
• "Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors". Acta Pharmacol. Sin. 25 (11): 1471–8. 2005. PMID 15525470.