Biology:Alpha-1D adrenergic receptor

From HandWiki
Short description: Protein-coding gene in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

The alpha-1D adrenergic receptor (α1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[1]

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.[1]

Ligands

Antagonists

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: ADRA1D adrenergic, alpha-1D-, receptor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=146. 
  2. ↑ "A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity". Eur. J. Pharmacol. 433 (1): 123–7. 2001. doi:10.1016/s0014-2999(01)01519-9. PMID 11755142. 
  3. ↑ "The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist". Autonomic and Autacoid Pharmacology 25 (4): 135–41. 2005. doi:10.1111/j.1474-8673.2005.00342.x. PMID 16176444. 

External links

Further reading

  • "Pharmacologic characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype.". Eur. J. Pharmacol. 227 (4): 433–6. 1992. doi:10.1016/0922-4106(92)90162-O. PMID 1359975. 
  • "Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor.". Biochem. Biophys. Res. Commun. 179 (3): 1485–90. 1991. doi:10.1016/0006-291X(91)91740-4. PMID 1656955. 
  • "Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells.". Mol. Pharmacol. 47 (5): 977–85. 1995. PMID 7746284. 
  • "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.". J. Pharmacol. Exp. Ther. 272 (1): 134–42. 1995. PMID 7815325. 
  • "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.". Biochem. Biophys. Res. Commun. 201 (3): 1296–304. 1994. doi:10.1006/bbrc.1994.1845. PMID 8024574. 
  • "Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5.". Cytogenet. Cell Genet. 67 (2): 69–74. 1994. doi:10.1159/000133802. PMID 8039425. 
  • "Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13.". Cytogenet. Cell Genet. 66 (3): 170–1. 1994. doi:10.1159/000133693. PMID 8125015. 
  • "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.". Mol. Pharmacol. 45 (4): 703–8. 1994. PMID 8183249. 
  • "Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes.". J. Neurochem. 74 (6): 2392–400. 2000. doi:10.1046/j.1471-4159.2000.0742392.x. PMID 10820200. 
  • "alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells.". Biochem. Biophys. Res. Commun. 272 (3): 906–11. 2000. doi:10.1006/bbrc.2000.2850. PMID 10860850. 
  • "Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis.". Cancer Res. 60 (16): 4550–5. 2000. PMID 10969806. 
  • "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D. 
  • "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1.". J. Biol. Chem. 278 (1): 672–8. 2003. doi:10.1074/jbc.M201375200. PMID 12409310. 
  • "Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.". J. Recept. Signal Transduct. Res. 23 (2–3): 185–95. 2004. doi:10.1081/RRS-120025200. PMID 14626446. 
  • "Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors". J. Biol. Chem. 279 (15): 15541–9. 2004. doi:10.1074/jbc.M314014200. PMID 14736874. 
  • "Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes". Endocrinology 145 (11): 5157–67. 2004. doi:10.1210/en.2004-0728. PMID 15297446. 
  • "Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors". Acta Pharmacol. Sin. 25 (11): 1471–8. 2005. PMID 15525470. 
  • "Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter". Neurourol. Urodyn. 24 (2): 142–8. 2005. doi:10.1002/nau.20097. PMID 15690361. 
  • "Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction". J. Biol. Chem. 281 (18): 12414–20. 2006. doi:10.1074/jbc.M508651200. PMID 16533813. 
  • "Epigenetic regulation of human α1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation". FASEB J. 21 (9): 1979–93. 2007. doi:10.1096/fj.06-7118com. PMID 17384146. 




Retrieved from "https://handwiki.org/wiki/index.php?title=Biology:Alpha-1D_adrenergic_receptor&oldid=2756403"