Chemistry:WB-4101
From HandWiki
Short description: Chemical compound
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| Formula | C19H23NO5 |
| Molar mass | 345.389 g·mol−1 |
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WB-4101 is a compound which acts as an antagonist at the α1B-adrenergic receptor. It was one of the first selective antagonists developed for this receptor and was invented in 1969, but is still commonly used in research into adrenergic receptors, especially as a lead compound from which to develop more selective drugs.[1][2][3][4][5][6]
See also
References
- ↑ "The synthesis and pharmacological properties of a series of 2-substituted aminomethyl-1,4-benzodioxanes". Journal of Medicinal Chemistry 12 (2): 326–9. March 1969. doi:10.1021/jm00302a033. PMID 5791620.
- ↑ "Characterization of alpha 1-adrenergic receptor subtypes in rat brain: a reevaluation of [3H]WB4104 and [3H]prazosin binding". Molecular Pharmacology 29 (4): 321–30. April 1986. PMID 3010073.
- ↑ "Search for selective antagonists at alpha 1-adrenoreceptors: neutral or negative antagonism?". Farmaco 53 (4): 278–86. April 1998. doi:10.1016/S0014-827X(98)00022-6. PMID 9658586.
- ↑ "Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety". Pharmaceutica Acta Helvetiae 74 (2–3): 181–90. March 2000. doi:10.1016/S0031-6865(99)00049-7. PMID 10812956.
- ↑ "Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist". European Journal of Medicinal Chemistry 58: 184–91. December 2012. doi:10.1016/j.ejmech.2012.09.049. PMID 23124215.
- ↑ "6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist". Journal of Medicinal Chemistry 56 (16): 6402–12. August 2013. doi:10.1021/jm400867d. PMID 23902232.
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