Chemistry:Tenilapine
From HandWiki
Short description: Atypical antipsychotic
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| Formula | C17H16N4S2 |
| Molar mass | 340.46 g·mol−1 |
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Tenilapine is an atypical antipsychotic which has never been marketed in the US.
Pharmacodynamics
Tenilapine has a relatively high affinity for the 5-HT2A receptor, and relatively low (micromolar) affinities for dopamine receptors.
| Receptor | Ki (nM) |
|---|---|
| D4 | 721±300[1] |
| 5-HT2A | 40[1] |
The ratio of D2 to D4 bonding is similar to that of clozapine.[1] Like many other atypical antipsychotics, it is a potent 5-HT2C antagonist.[2]
References
- ↑ 1.0 1.1 1.2 Cite error: Invalid
<ref>tag; no text was provided for refs namedroth - ↑ "The 5-HT2C Receptor Subtype Controls Central Dopaminergic Systems: Evidence from Electrophysiological and Neurochemical Studies". 5-HT2C Receptors in the Pathophysiology of CNS Disease. The Receptors. 22. Totowa, NJ: Humana Press. 2011. pp. 215–247. doi:10.1007/978-1-60761-941-3_11. ISBN 978-1-60761-940-6.
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