Chemistry:Benzamide

From HandWiki
Benzamide
Skeletal formula
Ball-and-stick model
Names
Preferred IUPAC name
Benzamide[1]
Systematic IUPAC name
Benzenecarboxamide
Other names
Benzoic acid amide
Phenyl carboxamide
Benzoylamide
Identifiers
3D model (JSmol)
3DMet
385876
ChEBI
ChEMBL
ChemSpider
EC Number
  • 200-227-7
KEGG
RTECS number
  • CU8700000
UNII
Properties
C7H7NO
Molar mass 121.139 g·mol−1
Appearance Off-white solid
Density 1.341 g/cm3
Melting point 127 to 130 °C (261 to 266 °F; 400 to 403 K)
Boiling point 288 °C (550 °F; 561 K)
13.5 g/L (at 25°C)[2]
Acidity (pKa)
  • approx. 13 (in H2O)[3]
  • 23.3 (in DMSO)[4]
-72.3·10−6 cm3/mol
Pharmacology
1=ATC code }} N05AL (WHO)
Hazards
GHS pictograms GHS07: HarmfulGHS08: Health hazard
GHS Signal word Warning
H302, H341
P201, P202, P264, P270, P281, P301+312, P308+313, P330, P405, P501
NFPA 704 (fire diamond)
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilHealth code 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineReactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no codeNFPA 704 four-colored diamond
1
1
0
Flash point 180 °C (356 °F; 453 K)
> 500 °C (932 °F; 773 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☑Y verify (what is ☑Y☒N ?)
Infobox references
Tracking categories (test):

Benzamide is an organic compound with the chemical formula of C7H7NO. It is the simplest amide derivative of benzoic acid. In powdered form, it appears as a white solid, while in crystalline form, it appears as colourless crystals.[5] It is slightly soluble in water,[2] and soluble in many organic solvents.[6] It is a natural alkaloid found in the herbs of Berberis pruinosa.[6]

Chemical derivatives

A number of substituted benzamides are commercial drugs, including:


See also

References

  1. Favre, Henri A.; Powell, Warren H. (2014). Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. p. 841. doi:10.1039/9781849733069-FP001. ISBN 9780854041824. OCLC 1077224056. https://books.google.com/books?id=4USgAgAAQBAJ. Retrieved 2022-10-11. 
  2. 2.0 2.1 "Benzamide | 55-21-0 supplier and manufacturer". https://www.buyersguidechem.com/chemical_supplier/benzamide#:~:text=soluble,25%C2%B0%20C. 
  3. Haynes, William M., ed (2016). CRC Handbook of Chemistry and Physics (97th ed.). CRC Press. p. 5–89 [sic]. ISBN 9781498754286. OCLC 1012162798. https://books.google.com/books?id=VVezDAAAQBAJ&dq=benzamide&pg=PA5-89. Retrieved 2022-10-11.  page cited is 5-89, not 5 to 89
  4. Bordwell, Frederick G.; Ji, Guo Zhen (October 1991). "Effects of structural changes on acidities and homolytic bond dissociation energies of the hydrogen-nitrogen bonds in amidines, carboxamides, and thiocarboxamides". Journal of the American Chemical Society 113 (22): 8398–8401. doi:10.1021/ja00022a029. https://pubs.acs.org/doi/abs/10.1021/ja00022a029. Retrieved 2022-10-11. 
  5. CID 2331 from PubChem
  6. 6.0 6.1 "benzamide, CAS number 55-21-0". https://www.thegoodscentscompany.com/data/rw1221711.html#:~:text=it%20is,organic%20solvents.. 
  7. Kent, James A.; Singh, K. N.; Merchant, Kavita (2012). "The Agrochemical Industry, Annex 17.1". in Kent, James A.. Handbook of Industrial Chemistry and Biotechnology. New York: Springer Verlag. pp. 643–698. doi:10.1007/978-1-4614-4259-2_17. ISBN 9781461442592. OCLC 1097100876. https://books.google.com/books?id=7VxDAAAAQBAJ&pg=PA693. Retrieved 2022-10-11. 

External links