Chemistry:Menadiol
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| Names | |||
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| Preferred IUPAC name
2-Methylnaphthalene-1,4-diol | |||
| Other names
2-Methyl-1,4-naphthalenediol; 2-Methyl-1,4-dihydroxynaphthalene
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| Identifiers | |||
3D model (JSmol)
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PubChem CID
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| Properties | |||
| C11H10O2 | |||
| Molar mass | 174.199 g·mol−1 | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |||
| Infobox references | |||
Menadiol is an organic compound with the formula C6H4(COH)2(CH)(CH3). It is formally a derivative of p-hydroquinone. The name vitamin K4 can refer to:
Menadiol sodium diphosphate is approved in the UK for treatment and prevention of haemorrhage, mainly in obstructive jaundice (before and after surgery).[6]
Menadiol is probably naturally produced by reduction of menadione ("vitamin K3"; see Quinone § Reduction) as an intermediate in the conversion from K3 to MK-4.[7] It can be oxidized in experimental conditions back to menadione.[8]
The menadiol core is apparent in the structure of vitamin K.
Menadiol diacetate
Menadiol dibutyrate
References
- ↑ "Anaphylactoid reactions to vitamin K". Journal of Thrombosis and Thrombolysis 11 (2): 175–183. 2001. doi:10.1023/A:1011237019082. ISSN 0929-5305. PMID 11406734.
- ↑ 2.0 2.1 2.2 The vitamins; chemistry, physiology, pathology, methods (2nd ed.). Academic Press. 1971. pp. 443. ISBN 9780126337631.
- ↑ "Vitamin K2 added for nutritional purposes in foods for particular nutritional uses, food supplements and foods intended for the general population and Vitamin K2 as a source of vitamin K added for nutritional purposes to foodstuffs, in the context of Regulation (EC) N° 258/97". EFSA Journal 6 (11): 822. 2008. doi:10.2903/j.efsa.2008.822. ISSN 1831-4732.
- ↑ 4.0 4.1 4.2 4.3 "US Pharmacopeial Convention safety evaluation of menaquinone-7, a form of vitamin K". Nutrition Reviews 75 (7): 553–578. 2017. doi:10.1093/nutrit/nux022. ISSN 0029-6643. PMID 28838081. https://academic.oup.com/nutritionreviews/article-abstract/75/7/553/3859571.
- ↑ "Kappadione". https://go.drugbank.com/drugs/DB09332.
- ↑ "Menadiol Diphosphate Tablets 10mg - Summary of Product Characteristics (SmPC) - (emc)". https://www.medicines.org.uk/emc/product/1349/smpc#gref.
- ↑ Shearer, Martin J.; Newman, Paul (March 2014). "Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis". Journal of Lipid Research 55 (3): 345–362. doi:10.1194/jlr.R045559. ISSN 0022-2275. PMID 24489112.
- ↑ Weber, Fritz; Rüttimann, August (2012). "Vitamin K". Ullmann's Encyclopedia Of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.o27_o08.
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