Chemistry:Prosultiamine

From HandWiki
Short description: Chemical compound
Prosultiamine
Skeletal formula of prosultiamine
Ball-and-stick model of the prosultiamine molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC15H24N4O2S2
Molar mass356.50 g·mol−1
3D model (JSmol)

Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is a homolog of allithiamine. It was developed as a treatment for vitamin B1 deficiency.[1][2] [3] It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.[4][5]

Research

It has been studied as a potential treatment for infection with human T-lymphotropic virus (HTLV), since it has been shown to reduce viral load and symptoms.[6]

See also

References

  1. Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. 
  2. Dictionary of pharmacological agents. London: Chapman & Hall. 1997. ISBN 0-412-46630-9. 
  3. ""allithiamine" A Newly Found Derivative of Vitamin B1". The Journal of Biochemistry 41: 29–39. 1954. doi:10.1093/oxfordjournals.jbchem.a126421. 
  4. "Thiamine propyl disulfide: absorption and utilization". Annals of Internal Medicine 74 (4): 529–534. April 1971. doi:10.7326/0003-4819-74-4-529. PMID 5551161. 
  5. "Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines". Journal of Nutritional Science and Vitaminology 22 SUPPL: 63–68. August 1976. doi:10.3177/jnsv.22.supplement_63. PMID 978282. 
  6. "Nervous System Disease: A New Outlet for an Old Drug?". Science Daily. 15 August 2013. https://www.sciencedaily.com/releases/2013/08/130815084757.htm.