Biology:PTK6

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.

Function

Tyrosine-protein kinase 6—also known as BRK (breast tumor kinase)—is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.

Clinical significance

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.

Interactions

PTK6 has been shown to interact with STAP2 and KHDRBS1.

Further reading

• "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases". Oncol. Res. 13 (6–10): 409–19. 2003. doi:10.3727/096504003108748438. PMID 12725532. 
• "Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours". Oncogene 9 (8): 2383–90. 1994. PMID 8036022. 
• "Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor". J. Biol. Chem. 271 (48): 30956–63. 1997. doi:10.1074/jbc.271.48.30956. PMID 8940083. 
• "Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase". Mol. Cells 8 (4): 401–7. 1998. PMID 9749526. 
• "BRK/Sik expression in the gastrointestinal tract and in colon tumors". Clin. Cancer Res. 5 (7): 1767–77. 1999. PMID 10430081. 
• "Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability". Mol. Cell. Biol. 20 (16): 6114–26. 2000. doi:10.1128/MCB.20.16.6114-6126.2000. PMID 10913193. 
• "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene 19 (37): 4273–82. 2000. doi:10.1038/sj.onc.1203775. PMID 10980601. 
• "Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation". Oncogene 19 (48): 5471–6. 2000. doi:10.1038/sj.onc.1203931. PMID 11114724. 
• "Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain". J. Biomol. NMR 19 (3): 291–2. 2001. doi:10.1023/A:1011221125013. PMID 11330822. 
• "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D. 
• "Characterization of the 5'-flanking region of the human PTK6 gene". Biochim. Biophys. Acta 1574 (3): 365–9. 2002. doi:10.1016/s0167-4781(02)00234-8. PMID 11997104. 
• "Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition". J. Biol. Chem. 277 (37): 34634–41. 2002. doi:10.1074/jbc.M203877200. PMID 12121988. 
• "Purification and spectroscopic characterization of the human protein tyrosine kinase-6 SH3 domain". J. Biochem. Mol. Biol. 35 (3): 343–7. 2002. doi:10.5483/BMBRep.2002.35.3.343. PMID 12297019. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Sam68 Enhances the Cytoplasmic Utilization of Intron-Containing RNA and Is Functionally Regulated by the Nuclear Kinase Sik/BRK". Mol. Cell. Biol. 23 (1): 92–103. 2003. doi:10.1128/MCB.23.1.92-103.2003. PMID 12482964. 
• "Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells". Oncogene 22 (27): 4212–20. 2003. doi:10.1038/sj.onc.1206465. PMID 12833144. 
• "Role of the Brk SH3 domain in substrate recognition". Oncogene 23 (12): 2216–23. 2004. doi:10.1038/sj.onc.1207339. PMID 14676834.