Biology:Megakaryocyte-associated tyrosine kinase
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.[1][2][3]
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.[3]
Interactions
Megakaryocyte-associated tyrosine kinase has been shown to interact with CD117[4][5] and TrkA.[6]
References
- ↑ "Identification and characterization of a novel tyrosine kinase from megakaryocytes". J Biol Chem 269 (2): 1068–74. February 1994. doi:10.1016/S0021-9258(17)42222-8. PMID 8288563.
- ↑ "Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product". J Biol Chem 270 (4): 1833–42. February 1995. doi:10.1074/jbc.270.4.1833. PMID 7530249.
- ↑ 3.0 3.1 "Entrez Gene: MATK megakaryocyte-associated tyrosine kinase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4145.
- ↑ Jhun, B H; Rivnay B; Price D; Avraham H (April 1995). "The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit". J. Biol. Chem. (UNITED STATES) 270 (16): 9661–6. doi:10.1074/jbc.270.16.9661. ISSN 0021-9258. PMID 7536744.
- ↑ Price, D J; Rivnay B; Fu Y; Jiang S; Avraham S; Avraham H (February 1997). "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes". J. Biol. Chem. (UNITED STATES) 272 (9): 5915–20. doi:10.1074/jbc.272.9.5915. ISSN 0021-9258. PMID 9038210.
- ↑ Yamashita, H; Avraham S; Jiang S; Dikic I; Avraham H (May 1999). "The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells". J. Biol. Chem. (UNITED STATES) 274 (21): 15059–65. doi:10.1074/jbc.274.21.15059. ISSN 0021-9258. PMID 10329710.
Further reading
- "CSK: a protein-tyrosine kinase involved in regulation of src family kinases.". J. Biol. Chem. 266 (36): 24249–52. 1992. doi:10.1016/S0021-9258(18)54220-4. PMID 1722201.
- "Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes.". Oncogene 9 (7): 2037–44. 1994. PMID 7516063.
- "The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit.". J. Biol. Chem. 270 (16): 9661–6. 1995. doi:10.1074/jbc.270.16.9661. PMID 7536744.
- "Characterization of mouse non-receptor tyrosine kinase gene, HYL.". Oncogene 9 (11): 3371–4. 1994. PMID 7936664.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase).". Oncogene 9 (4): 1155–61. 1994. PMID 8134117.
- "Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells.". J. Biol. Chem. 272 (3): 1856–63. 1997. doi:10.1074/jbc.272.3.1856. PMID 8999872.
- "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.". J. Biol. Chem. 272 (9): 5915–20. 1997. doi:10.1074/jbc.272.9.5915. PMID 9038210.
- "Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets.". EMBO J. 16 (9): 2342–51. 1997. doi:10.1093/emboj/16.9.2342. PMID 9171348.
- "The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e.". Growth Factors 14 (2–3): 103–15. 1997. doi:10.3109/08977199709021514. PMID 9255603. https://zenodo.org/record/1235827.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "The Csk homologous kinase, Chk, binds tyrosine phosphorylated paxillin in human blastic T cells.". Biochem. Biophys. Res. Commun. 256 (3): 668–75. 1999. doi:10.1006/bbrc.1999.0398. PMID 10080957. https://zenodo.org/record/1229494.
- "The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells.". J. Biol. Chem. 274 (21): 15059–65. 1999. doi:10.1074/jbc.274.21.15059. PMID 10329710.
- "Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration.". Int. J. Oncol. 21 (1): 197–205. 2002. doi:10.3892/ijo.21.1.197. PMID 12063569.
- "Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer.". J. Biol. Chem. 277 (39): 36465–70. 2002. doi:10.1074/jbc.M206018200. PMID 12122014.
- "Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells.". Int. J. Oncol. 21 (6): 1347–52. 2003. doi:10.3892/ijo.21.6.1347. PMID 12429987.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Conserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHK.". FEBS Lett. 544 (1–3): 11–4. 2003. doi:10.1016/S0014-5793(03)00405-8. PMID 12782282.
PDB gallery | |
|---|---|
|
 |  |
