Biology:LCOR

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.[1][2][3]

Function

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.[3]

References

  1. "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms". Mol Cell 11 (1): 139–50. Jan 2003. doi:10.1016/S1097-2765(03)00014-5. PMID 12535528. 
  2. "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm. Vitamins & Hormones 68: 123–43. Jun 2004. doi:10.1016/S0083-6729(04)68004-6. ISBN 9780127098685. PMID 15193453. 
  3. 3.0 3.1 "Entrez Gene: LCOR ligand dependent nuclear receptor corepressor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84458. 

Further reading

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Ligand-dependent corepressor