Biology:Galanin-like peptide
| Galanin-like peptide | |
|---|---|
| Identifiers | |
| Symbol | GALP |
| NCBI gene | 85569 |
| HGNC | 24840 |
| OMIM | 611178 |
| RefSeq | NM_033106 |
| UniProt | Q9UBC7 |
| Other data | |
| Locus | Chr. 19 q13.42 |
Galanin-like peptide (GALP) is a neuropeptide present in humans and other mammals. It is a 60-amino acid polypeptide produced in the arcuate nucleus of the hypothalamus and the posterior pituitary gland.[1][2][3] It is involved in the regulation of appetite and may also have other roles such as in inflammation, sex behavior, and stress.[4][5][6][7][8][9]
Findings additionally suggest that GALP could play a function in energy metabolism due to its ability to maintain continual activation of the sympathetic nervous system (SNS) via thermogenesis, which refers to the production of heat within living organisms.[10] In addition, the administration of GALP directly into the brain leads to a reduction in the secretion of thyroid-stimulating hormone (TSH), which indicates the involvement of GALP in the neuroendocrine regulation of the hypothalamic-pituitary-thyroid (HPT) axis, and further adding to the evidence of the role of GALP in energy homeostasis.[11]
Notes
- ↑ "Effects of galanin-like peptide on food intake and the hypothalamo-pituitary-thyroid axis". Neuroendocrinology 77 (2): 125–31. February 2003. doi:10.1159/000068648. PMID 12624534.
- ↑ "Galanin-like peptide in the brain: effects on feeding, energy metabolism and reproduction". Regulatory Peptides 126 (1–2): 21–6. March 2005. doi:10.1016/j.regpep.2004.08.029. PMID 15620409.
- ↑ "Morphological interaction between galanin-like peptide- and dopamine-containing neurons in the rat arcuate nucleus". Regulatory Peptides 145 (1–3): 165–8. January 2008. doi:10.1016/j.regpep.2007.08.019. PMID 17916390.
- ↑ "Galanin-like peptide: a role in the homeostatic regulation of energy balance?". Neuropharmacology 55 (1): 1–7. July 2008. doi:10.1016/j.neuropharm.2008.04.008. PMID 18538801.
- ↑ "Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat". Endocrinology 147 (4): 1744–52. April 2006. doi:10.1210/en.2005-0907. PMID 16410310.
- ↑ "Galanin-like peptide stimulates feeding and sexual behavior via dopaminergic fibers within the medial preoptic area of adult male rats". Journal of Chemical Neuroanatomy 37 (2): 105–11. March 2009. doi:10.1016/j.jchemneu.2008.12.003. PMID 19124073.
- ↑ "Interleukin-1 mediates the anorexic and febrile actions of galanin-like Peptide". Endocrinology 149 (11): 5791–802. November 2008. doi:10.1210/en.2008-0252. PMID 18617619.
- ↑ Lawrence CB (July 2009). "Galanin-like peptide modulates energy balance by affecting inflammatory mediators?". Physiology & Behavior 97 (5): 515–9. doi:10.1016/j.physbeh.2009.02.041. PMID 19298833.
- ↑ "Pathophysiological roles of galanin-like peptide in the hypothalamus and posterior pituitary gland". Pathophysiology 17 (2): 135–140. June 2009. doi:10.1016/j.pathophys.2009.03.007. PMID 19501488.
- ↑ Shiba, Kanako; Kageyama, Haruaki; Takenoya, Fumiko; Shioda, Seiji (2010). "Galanin-like peptide and the regulation of feeding behavior and energy metabolism". The FEBS Journal 277 (24): 5006–5013. doi:10.1111/j.1742-4658.2010.07933.x. PMID 21126314.
- ↑ Lawrence, Catherine; Fraley, Gregory S. (2011). "Galanin-like peptide (GALP) is a hypothalamic regulator of energy homeostasis and reproduction". Frontiers in Neuroendocrinology 32 (1): 1–9. doi:10.1016/j.yfrne.2010.06.001. PMID 20558195.
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