Biology:dnaN

From HandWiki

DNA polymerase III subunit beta
E coli beta clamp 1MMI.png
Crystallographic structure of the dimeric DNA polymerase beta subunit from E. coli.[1]
Identifiers
OrganismEscherichia coli
(str. K-12 substr. MG1655)
SymboldnaN
Entrez948218
PDB1MMI (ECOD)
RefSeq (Prot)NP_418156
UniProtP0A988
Other data
EC number2.7.7.7
ChromosomeMG1655: 3.88 - 3.88 Mb

dnaN is the gene that codes for the DNA clamp (also known as β sliding clamp) of DNA polymerase III in prokaryotes.[2][3] The β clamp physically locks Pol III onto a DNA strand during replication to help increase its processivity.[4] The eukaryotic equivalent to the β clamp is PCNA.

See also

  • Beta clamp

References

  1. PDB: 1MMI​; "Flexibility revealed by the 1.85 Å crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III". Acta Crystallogr. D 59 (Pt 7): 1192–9. July 2003. doi:10.1107/S0907444903009958. PMID 12832762. http://espace.library.uq.edu.au/view/UQ:39327/UQ39327_OA.pdf. 
  2. "Structural analysis of the dnaA and dnaN genes of Escherichia coli". Gene 28 (2): 159–70. May 1984. doi:10.1016/0378-1119(84)90253-1. PMID 6234204. 
  3. "Transcriptional organization of the dnaN and recF genes of Escherichia coli K-12". J. Biol. Chem. 263 (24): 12109–14. August 1988. PMID 2841344. 
  4. "Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme". J. Biol. Chem. 266 (17): 11328–34. June 1991. PMID 2040637. http://www.jbc.org/content/266/17/11328.abstract.