Place:Stromal vascular fraction
Stromal vascular fraction | |
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 Stromal Vascular Fraction |
Stromal vascular fraction (SVF) of adipose tissue is a source of preadipocytes, mesenchymal stem cells (MSC), endothelial progenitor cell, T cells, B cells, mast cells as well as adipose tissue macrophages.[1][2]
Introduction
Stromal Vascular Fraction (SVF) is a component of the lipoaspirate obtained from liposuction of excess adipose tissue. Lipoaspirate, the waste product of liposuction (cosmetic surgery), contains a large population of regenerative cells called adipose derived regenerative cells (ADRCs), which share a number of similarities with bone marrow cells, including the capacity for multilineage differentiation. Autologous SVFs containing ADRCs are currently being used in clinical settings for various orthopedic applications for human patients without any serious side effects.[3][4][5][6]
References
- ↑ Riordan, Neil H; Ichim, Thomas E; Min, Wei-Ping; Wang, Hao; Solano, Fabio; Lara, Fabian; Alfaro, Miguel; Rodriguez, Jorge et al. (2009). "Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis". Journal of Translational Medicine 7: 29. doi:10.1186/1479-5876-7-29. PMID 19393041.
- ↑ Schipper, Henk S; Prakken, Berent; Kalkhoven, Eric; Boes, Marianne (2012). "Adipose tissue-resident immune cells: Key players in immunometabolism". Trends in Endocrinology & Metabolism 23 (8): 407–15. doi:10.1016/j.tem.2012.05.011. PMID 22795937.
- ↑ Pak, Jaewoo; Lee, Jung Hun; Park, Kwang Seung; Park, Moonhee; Kang, Lin-Woo; Lee, Sang Hee (2017). "Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications". Journal of Biomedical Science 24 (1): 9. doi:10.1186/s12929-017-0318-z. PMID 28143470.
- ↑ Pak, Jaewoo; Lee, Jung Hun; Park, Kwang Seung; Jeon, Jeong Ho; Lee, Sang Hee (2017). "Potential use of mesenchymal stem cells in human meniscal repair: Current insights". Open Access Journal of Sports Medicine 8: 33–38. doi:10.2147/OAJSM.S113018. PMID 28356779.
- ↑ Zhang, Jinxin; Du, Chunyan; Guo, Weimin; Li, Pan; Liu, Shuyun; Yuan, Zhiguo; Yang, Jianhua; Sun, Xun et al. (2017). "Adipose Tissue-Derived Pericytes for Cartilage Tissue Engineering". Current Stem Cell Research & Therapy 12 (6): 513–21. doi:10.2174/1574888X12666170321111211. PMID 28325151.
- ↑ Pak, J.; Lee, J. H.; Pak, N. J.; Park, K. S.; Jeon, J. H.; Jeong, B. C.; Lee, S. H. (2018). "Clinical protocol of producing adipose tissue-derived stromal vascular fraction for potential cartilage regeneration" (in en). Journal of Visualized Experiments 139: e58363. doi:10.3791/58363. PMID 30320755.
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