Company:DNA2.0

From HandWiki
DNA2.0 (now ATUM)
TypePrivate
IndustryBiotechnology
Founded2003
FoundersSridhar Govindarajan, Claes Gustafsson, Jeremy Minshull, Jon Ness
Headquarters
Newark, California
,
United States
ProductsGene Synthesis, Protein Engineering, Protein Production, Bioinformatics, Cell line development, Leap-In transposases
Websitewww.atum.bio

DNA2.0 is now ATUM provides products and services for life science and Synthetic biology research. DNA2.0/ATUM also provides free access to research tools such as Gene Designer, DNA Atlas and a gRNA designer.

The company

DNA2.0 (now ATUM) was founded in 2003, in Menlo Park, California . The company is privately held[1] and continues to have all research, development and production in California, currently in their 50,000 sq ft Newark facility.[2] It began and continues as a gene synthesis and protein engineering provider to academia, government and the pharmaceutical, chemical, agricultural and biotechnology industries. Gene Synthesis rapidly replaced molecular cloning for many academic and corporate labs, as "foundries for the biotechnology age" allowing made-to-order genes for biological research.[3] DNA2.0 was featured on the PBS show Nova ScienceNow[4] to show how genes are created synthetically in a lab. In 2008, the company supplied some of the DNA stretches used to create a synthetic bacterial genome.[5] Dan Rather Reports included DNA2.0 in their episode on Synthetic Biology[6] and how it is solving "some of the most important problems facing the world."[6] In 2009, The Scientist named the codon design algorithms[7] (now trademarked as GeneGPS) developed by DNA2.0 as one of the Top 10 Innovations of the year for Life Sciences.[8] DNA2.0 developed the Electra Vector System, a universal cloning system that utilizes the type IIS restriction enzyme SapI and T4 DNA ligase in a single-tube reaction.[9] DNA2.0 has made some molecular components, such as synthetic fluorescent proteins, available in open-access collections of DNA parts (BioBricks Foundation).[10] DNA2.0 is a founding member of the International Gene Synthesis Consortium (IGSC) to promote biosecurity in the gene-synthesis industry.[11][12] There are over 1,200[13] published scientific articles using DNA2.0 products and/or services, of which 44[14] include company employees as an author(s).

Research Tools

Partnerships

  • The Perelman School of Medicine at the University of Pennsylvania will use the GeneGPS technology developed by DNA2.0 primarily to support the Gene Therapy Program’s work on HIV-1 vaccine development by optimizing in vivo protein expression.[20][21]
  • The Infection and Immunity Research Centre at St. George’s, University of London and DNA2.0 partnered to develop plant-based pharmaceuticals.[22]
  • Adimab LLC. and DNA2.0 employ an alliance in the area of antibody discovery and biomanufacturing via the design and construction of antibody libraries.
  • Cytovance Biologics utilizes GeneGPS from DNA2.0 as part of their Keystone Expression System for microbial strain development for successful biomanufacturing.
  • Archer Daniels Midland Company applies DNA2.0's proprietary protein engineering technology, ProteinGPS, to ADM’s industrial enzyme engineering processes.[23]
  • DNA2.0 is a sponsor of BioBuilder, a resource for hands-on activities and informative animations on synthetic biology for middle school and high school students and teachers; founded by Dr. Natalie Kuldell at MIT.

Patents

Minshull & Theodorou, "Fluorescent and colored proteins and methods for using them", US patent 9290552, issued March 22, 2016

Minshull; Ness & Theodorou, "Methods, compositions and kits for a one-step DNA cloning system", US patent 9206433, issued December 8, 2015

Ness & Minshull, "Methods, compositions and kits for one-step DNA cloning using DNA topoisomerase", US patent 9102944, issued August 11, 2015

Minshull & Theodorou, "Fluorescent and colored proteins and methods for using them", US patent 8975042, issued March 10, 2015

Govindarajan; Minshull & Ness, "Design, synthesis and assembly of synthetic nucleic acids", US patent 8825411, issued September 2, 2014

Gustafsson; Govindarajan & Minshull, "Systems and methods for biopolymer engineering", US patent 8635029, issued January 21, 2014

Gustafsson; Govindarajan & Minshull, "Systems and methods for antibody engineering", US patent 8412461, issued April 2, 2013

Welch & Gustafsson, "Systems and methods for constructing frequency lookup tables for expression systems", US patent 8401798, issued March 19, 2013

Ness & Minshull, "Methods, compositions and kits for one-step DNA cloning using DNA topoisomerase", US patent 8323930, issued December 4, 2012

Gross; Lu & Ness et al., "Production of an .alpha.-carboxyl-.omega.-hydroxy fatty acid using a genetically modified Candida strain", US patent 8158391, issued September 28, 2010

Welch & Gustafsson, "Synthetic nucleic acids for expression of encoded proteins", US patent 8126653, issued February 28, 2012

Gustafsson; Govindarajan & Minshull, "Systems and methods for biopolymer engineering", US patent 8005620, issued August 23, 2011

Gustafsson; Govindarajan & Ness et al., "Systems and methods for designing and ordering polynucleotides", US patent 7805252, issued September 28, 2010

Welch & Gustafsson, "Methods for determining properties that affect an expression property value of polynucleotides in an expression system", US patent 7561973, issued July 14, 2009

Welch & Gustafsson, "Synthetic nucleic acids for expression of encoded proteins", US patent 7561972, issued July 14, 2009

References

  1. ↑ Duan, Mary (October 18, 2009). "Gene synthesis: It’s no strain for DNA 2.0". Silicon Valley Business Journal (San Jose, CA). http://www.bizjournals.com/sanjose/stories/2009/10/19/focus1.html. 
  2. ↑ "DNA2.0 Builds State of the Art Bioproduction Facility in Newark, California". The San Jose Mercury News. http://markets.financialcontent.com/mng-ba.mercurynews/news/read/31760923/DNA2.0_Builds_State_of_the_Art_Bioproduction_Facility_in_Newark. Retrieved 22 March 2016. 
  3. ↑ Pollack (September 12, 2007). "How Do You Like Your Genes? Biofabs Take Orders". The New York Times (New York). https://www.nytimes.com/2007/09/12/technology/techspecial/12gene.html?_r=1&oref=slogin. 
  4. ↑ "Artificial Life". Nova ScienceNow. October 18, 2005. PBS.
  5. ↑ Pollack (January 24, 2008). "Scientists Take New Step Toward Man-Made Life". The New York Times (New York). https://www.nytimes.com/2008/01/24/science/24cnd-genome.html?scp=1&sq=Scientists%20Take%20New%20Step%20Toward%20Man&st=cse&_r=0. 
  6. ↑ 6.0 6.1 "Cutting Edge". Dan Rather Reports. April 30, 2013. AXS TV.
  7. ↑ Welch; Govindarajan; Ness; Villalobos; Gurney; Minshull; Gustafsson (September 14, 2009). "Design parameters to control synthetic gene expression in Escherichia coli.". PLOS ONE 4 (9): e7002. doi:10.1371/journal.pone.0007002. PMID 19759823. PMC 2736378. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007002. 
  8. ↑ "2009 Top 10 Innovations". The Scientist 23 (12): 41–52. December 1, 2009. 
  9. ↑ Whitman; Gore; Ness; Theodorou; Minshull (June 2013), "Rapid, Scarless Cloning of Gene Fragments Using SapI, T4 DNA Ligase and the DNA2.0 Electra Vector System", NEB Expressions II: 8, https://www.neb.com/~/media/NebUs/Files/Expressions/Expressions_IssueII_0613.pdf 
  10. ↑ Ledford, Heidi (July 4, 2013). "Bioengineers Look Beyond Patents". Nature (Macmillan Publishers Limited) 499: 16–17. doi:10.1038/499016a. PMID 23823774. http://www.nature.com/news/bioengineers-look-beyond-patents-1.13320. 
  11. ↑ Hayden, Erika Check (November 18, 2009). "Gene-makers form security coalition". Nature. doi:10.1038/news.2009.1095. http://www.nature.com/news/2009/091118/full/news.2009.1095.html. 
  12. ↑ "Gene-Synthesis Firms Set Up Biosecurity Protocol", Genetic Engineering & Biotechnology News, November 18, 2009, http://www.genengnews.com/gen-news-highlights/gene-synthesis-firms-set-up-biosecurity-protocol/68850005/ 
  13. ↑ "Literature Database Search All". April 29, 2016. https://www.dna20.com/resources/literature-database?ldb_year=0-3000. 
  14. ↑ "Literature Database Search Author Affiliation:DNA2.0". April 29, 2016. https://www.dna20.com/resources/literature-database?ldb_affiliation=DNA. 
  15. ↑ Villalobos, Alan; Ness, Jon E; Gustafsson, Claes; Minshull, Jeremy; Govindarajan, Sridhar (2006). "Gene Designer: A synthetic biology tool for constructing artificial DNA segments". BMC Bioinformatics 7: 285. doi:10.1186/1471-2105-7-285. PMID 16756672. 
  16. ↑ Villalobos, Alan; Welch, Mark; Minshull, Jeremy (2012). "In Silico Design of Functional DNA Constructs". Gene Synthesis. Methods in Molecular Biology 852: 197–213. doi:10.1007/978-1-61779-564-0_15. ISBN 978-1-61779-563-3. PMID 22328435. 
  17. ↑ Welch, M; Villalobos, A; Gustafsson, C; Minshull, J (2011). "Designing genes for successful protein expression". Methods in Enzymology 498: 43–66. doi:10.1016/B978-0-12-385120-8.00003-6. PMID 21601673. 
  18. ↑ Dance, Amber (July 1, 2012). "Mover Over, Mother Nature.". The Scientist. http://www.the-scientist.com/?articles.view/articleNo/32275/title/Move-Over--Mother-Nature/. 
  19. ↑ "Best of the Web". Genetic Engineering News. April 15, 2007. 
  20. ↑ "Optimizing Gene Expression with DNA2.0 Technology.". GEN. November 14, 2012. http://www.genengnews.com/gen-news-highlights/optimizing-b-gene-b-b-expression-b-with-dna2-0-technology/81247634/. 
  21. ↑ McEnery, Regina (February 4, 2013), "Delivering the DNA", VAX The Bulletin on AIDS Vaccine Research 11 (1), http://www.vaxreport.org/Back-Issues/Pages/Delivering-the-DNA.aspx 
  22. ↑ Cohen, Bryan (December 24, 2013). "DNA2.0 Announces Biopharmaceutical Partnership with St. George's". Vaccine News. http://vaccinenewsdaily.com/medical_countermeasures/329037-dna2-0-announces-biopharmaceutical-partnership-with-st-georges/. 
  23. ↑ "ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement.". San Jose Mercury News (San Jose, CA). November 17, 2014. http://markets.financialcontent.com/mng-ba.mercurynews/news/read/28924252/ADM_and_DNA2.0_Enter_Into_Protein_Engineering_Technology_Access_and_Service_Agreement. 

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