Chemistry:Verinurad
From HandWiki
Short description: Chemical compound
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| Other names | RDEA-3170; RDEA3170 |
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| Formula | C20H16N2O2S |
| Molar mass | 348.42 g·mol−1 |
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Verinurad is a selective URAT1 inhibitor developed for gout and heart failure by AstraZeneca.[1][2][3]
References
- ↑ Johansson, Susanne; Han, David; Hunt, Thomas; Björck, Karin; Florica, Delia; Gillen, Michael; Hall, Jesse; Erlandsson, Fredrik (June 2022). "Pharmacokinetics, pharmacodynamics, and safety of verinurad with and without allopurinol in healthy Asian, Chinese, and non-Asian participants". Pharmacology Research & Perspectives 10 (3): e00929. doi:10.1002/prp2.929. PMID 35593744.
- ↑ Fitz-Patrick, David; Roberson, Kent; Niwa, Kiyoshi; Fujimura, Takabumi; Mori, Koji; Hall, Jesse; Yan, Xiaohong; Shen, Zancong et al. (2 November 2019). "Safety and efficacy of verinurad, a selective URAT1 inhibitor, for the treatment of patients with gout and/or asymptomatic hyperuricemia in the United States and Japan: Findings from two phase II trials". Modern Rheumatology 29 (6): 1042–1052. doi:10.1080/14397595.2018.1538003. PMID 30334639.
- ↑ Tan, Philip K.; Liu, Sha; Gunic, Esmir; Miner, Jeffrey N. (6 April 2017). "Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout" (in en). Scientific Reports 7 (1): 665. doi:10.1038/s41598-017-00706-7. ISSN 2045-2322. PMID 28386072. Bibcode: 2017NatSR...7..665T.
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