Chemistry:Tazobactam

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Short description: Chemical compound


Tazobactam
Tazobactam structure.svg
Tazobactam-from-xtal-3D-bs-17.png
Clinical data
AHFS/Drugs.comInternational Drug Names
License data
Pregnancy
category
  • B
Routes of
administration
Intravenous
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC10H12N4O5S
Molar mass300.29 g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. It is commonly used as its sodium salt, tazobactam sodium.

Tazobactam is combined with the extended spectrum β-lactam antibiotic piperacillin in the drug piperacillin/tazobactam, used in infections due to Pseudomonas aeruginosa. Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express β-lactamase and would normally degrade piperacillin.[1]

Tazobactam was patented in 1982 and came into medical use in 1992.[2]

See also

References

  1. "Class A beta-lactamases--enzyme-inhibitor interactions and resistance". Pharmacology & Therapeutics 83 (2): 141–151. August 1999. doi:10.1016/S0163-7258(99)00027-3. PMID 10511459. 
  2. (in en) Analogue-based Drug Discovery. John Wiley & Sons. 2006. p. 490. ISBN 9783527607495. https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA490.