Chemistry:TDI-11861
From HandWiki
Short description: Chemical compound
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| Formula | C22H25ClF2N6O3 |
| Molar mass | 494.93 g·mol−1 |
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TDI-11861 is a chemical compound which acts as a potent [1] and selective inhibitor of soluble adenylyl cyclase (sAC).[2] In animal studies it reversibly inhibits sperm motility, producing temporary infertility without hormonal side effects. While TDI-11861 is at an early developmental stage and is unlikely to be developed for medical uses in humans itself, it represents an important proof of concept which may potentially lead to the development of future male contraceptive drugs.[3][4]
See also
References
- ↑ "Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential". Frontiers in Physiology 13: 1013845. 28 September 2022. doi:10.3389/fphys.2022.1013845. PMID 36246105.
- ↑ "Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates". Journal of Medicinal Chemistry 65 (22): 15208–15226. November 2022. doi:10.1021/acs.jmedchem.2c01133. PMID 36346696.
- ↑ "On-demand male contraception via acute inhibition of soluble adenylyl cyclase". Nature Communications 14 (1): 637. February 2023. doi:10.1038/s41467-023-36119-6. PMID 36788210. Bibcode: 2023NatCo..14..637B.
- ↑ Balbach M, et al., "Soluble Adenylyl Cyclase (sAC) Inhibitors and Uses Thereof", WO patent 2022/232259, published 3 November 2022, assigned to Cornell Universityand Tri-Institutional Therapeutics Discovery Institute, Inc.
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