Chemistry:Ro01-6128
From HandWiki
Short description: Chemical compound
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| Formula | C17H17NO3 |
| Molar mass | 283.327 g·mol−1 |
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Ro01-6128 is a drug used in scientific research, which acts as a selective positive allosteric modulator for the metabotropic glutamate receptor subtype mGluR1.[1][2][3] It was derived by modification of a lead compound found via high-throughput screening, and was further developed to give the improved compound Ro67-4853.[4]
References
- ↑ "Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site". Proceedings of the National Academy of Sciences of the United States of America 98 (23): 13402–7. November 2001. doi:10.1073/pnas.231358298. PMID 11606768. Bibcode: 2001PNAS...9813402K.
- ↑ "A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators". Molecular Pharmacology 70 (2): 616–26. August 2006. doi:10.1124/mol.105.021857. PMID 16645124.
- ↑ "Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells". Neuropharmacology 55 (4): 419–27. September 2008. doi:10.1016/j.neuropharm.2008.06.047. PMID 18625258.
- ↑ "Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors". Farmaco 57 (12): 989–92. December 2002. doi:10.1016/s0014-827x(02)01283-1. PMID 12564473.
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