Chemistry:Ro-318220

Ro-318220
Names
	Preferred IUPAC name 3-{3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl carbamimidothioate
Identifiers
CAS Number	125314-64-9 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:38912;
ChEMBL	ChEMBL6291;
ChemSpider	4905;
PubChem CID	5083;
UNII	W9A0B5E78O ;
	InChI InChI=1S/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32) Key: DSXXEELGXBCYNQ-UHFFFAOYSA-N; InChI=1/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32) Key: DSXXEELGXBCYNQ-UHFFFAOYAO;
	SMILES Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCSC(=N)N)c4ccccc34)c5ccccc15;
Properties
Chemical formula	C25H23N5O2S
Molar mass	457.55 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class.^[1]

References

↑ Beltman, Jerlyn; Frank McCormick; Simon J. Cook (1996). "The Selective Protein Kinase C Inhibitor, Ro-31-8220, Inhibits Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression, Induces c-Jun Expression, and Activates Jun N-terminal Kinase". Journal of Biological Chemistry 271: 27018–27024. doi:10.1074/jbc.271.43.27018.

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