Chemistry:Plectasin
Plectasin is an antibiotic protein from the mushroom Pseudoplectania nigrella. It was initially discovered in 2005[1] and commercialised by Novozymes.[2] Plectasin belongs to the antimicrobial peptide class called fungal defensins, which is also present in invertebrates such as flies and mussels.[citation needed]
Clinical trials
Pre-clinical tests in mice have shown promising results in that multiresistant bacteria have problems mutating resistance against plectasin,[3] which acts by directly binding the bacterial cell-wall precursor Lipid II.[4]
At the end of 2008, Novozymes signed a global licensing agreement with Sanofi-Aventis for the further development and marketing of NZ2114, a derivative of plectasin, as a treatment for gram-positive bacterial infections, e.g. Streptococcus and Staphylococcus which are resistant to all existing antibiotics.[2][5]
References
- ↑ Mygind, Per H.; Fischer, Rikke L.; Schnorr, Kirk M.; Hansen, Mogens T.; Sönksen, Carsten P.; Ludvigsen, Svend; Raventós, Dorotea; Buskov, Steen et al. (2005). "Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus" (in en). Nature 437 (7061): 975–980. doi:10.1038/nature04051. ISSN 1476-4687. PMID 16222292. Bibcode: 2005Natur.437..975M.
- ↑ 2.0 2.1 "Novozymes reveals knowledge on new antibiotic against resistant bacteria". Novozymes. 2010-05-28. http://www.novozymes.com/en/MainStructure/PressAndPublications/PressRelease/2010/Plectasin+in+Science.htm.
- ↑ "Plectasin NZ2114 - Novel Microbial Agent". Drug Development Technology. http://www.drugdevelopment-technology.com/projects/plectasin/.
- ↑ Kristensen, HH (2010). "Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II". Science 328 (5982): 1168–1172. doi:10.1126/science.1185723. PMID 20508130. Bibcode: 2010Sci...328.1168S.
- ↑ Kristensen, HH (2009). "In Vivo Pharmacodynamic Characterization of a Novel Plectasin Antibiotic, NZ2114, in a Murine Infection Model". Antimicrob. Agents Chemother. 53 (7): 3003–3009. doi:10.1128/AAC.01584-08. PMID 19414576.
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