Chemistry:Pheophorbide

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Pheophorbide a
Pheophorbide a.svg
Names
IUPAC name
(3S,4S)-9-Ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
EC Number
  • 239-738-5
KEGG
UNII
Properties
C35H36N4O5
Molar mass 592.68 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Pheophorbide or phaeophorbide is a product of chlorophyll breakdown and a derivative of pheophytin where both the central magnesium has been removed and the phytol tail has been hydrolyzed. It is used as a photosensitizer in photodynamic therapy.[1]

Pheophorbide may be generated by digestion of ingested plant matter. Both worm (Caenorhabditis elegans) and mouse mitochondria are able to use the molecule in a form of ad hoc photoheterotrophy.[2]

References

  1. Chen, K. (2009). "Novel photosensitizer-protein nanoparticles for Photodynamic therapy: Photophysical characterization and in vitro investigations". Journal of Photochemistry and Photobiology B: Biology 96 (1): 66–74. doi:10.1016/j.jphotobiol.2009.04.006. PMID 19442534. 
  2. Xu, Chen; Zhang, Junhua; Mihai, Doina M.; Washington, Ilyas (2014-01-15). "Light-harvesting chlorophyll pigments enable mammalian mitochondria to capture photonic energy and produce ATP" (in en). Journal of Cell Science 127 (2): 388–399. doi:10.1242/jcs.134262. ISSN 0021-9533. PMID 24198392.