Chemistry:PD 144418

Short description: Chemical compound

PD 144418

Identifiers
IUPAC name 1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine
CAS Number	154130-99-1
ChemSpider	7992981
Chemical and physical data
Formula	C18H22N2O
Molar mass	282.387 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCN1CCC=C(C1)C2=CC(=NO2)C3=CC=C(C=C3)C
InChI InChI=1S/C18H22N2O/c1-3-10-20-11-4-5-16(13-20)18-12-17(19-21-18)15-8-6-14(2)7-9-15/h5-9,12H,3-4,10-11,13H2,1-2H3 Key:FOQRKFCLRMMKAT-UHFFFAOYSA-N

PD 144418 or 1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine is a potent and selective ligand for the sigma-1 receptor, with a reported binding affinity of K_i = 0.08 ± 0.01 nM, and 17 212 times selectivity over the sigma-2 receptor.