Chemistry:Nitrile reduction

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In nitrile reduction a nitrile is reduced to either an amine or an aldehyde with a suitable chemical reagent.[1][2]

Catalytic hydrogenation

The catalytic hydrogenation of nitriles is often the most economical route available for the production of primary amines.[3] Catalysts for the reaction often include group 10 metals such as Raney nickel,[4][5][6] palladium black, or platinum dioxide.[1] However, other catalysts, such as cobalt boride, also can be regioselective for primary amine production:

R-C≡N + 2 H2 → R-CH2NH2

A commercial application of this technology includes the production of hexamethylenediamine from adiponitrile, a precursor to Nylon 66.[7]

Depending on reaction conditions, reactive intermediate imines can also undergo attack by amine products to afford secondary and tertiary amines:

2 R-C≡N + 4 H2 → (R-CH2)2NH + NH3
3 R-C≡N + 6 H2 → (R-CH2)3N + 2 NH3

Such reactions proceed via enamine intermediates.[8] The most important reaction condition for selective primary amine production is catalyst choice.[1] Other important factors include solvent choice, solution pH, steric effects, temperature, and the pressure of hydrogen.

Stoichiometric reductions

To amines

Reducing agents for the non-catalytic conversion to amines include lithium aluminium hydride, lithium borohydride,[9] diborane,[10] or elemental sodium in alcohol solvents.[11]

To aldehydes

Nitriles can also be converted to aldehydes by reduction and hydrolysis. The Stephen aldehyde synthesis uses Tin(II) chloride and hydrochloric acid to yield an aldehyde via the hydrolysis of a resulting iminium salt. Aldehydes can also form using a hydrogen donor followed by in-situ hydrolysis of an imine. Useful reagents for this reaction include formic acid with a hydrogenation catalysis[12] or metal hydrides, which are used to add one mol of hydrogen to the nitrile. For example, sodium borohydride reduces nitriles in alcoholic solvents with a CoCl2 catalyst or Raney nickel.[13]

With diisobutylaluminium hydride

File:DIBAL mechanism .tif The hydride reagent Diisobutylaluminium hydride, or DIBAL-H, is commonly used to convert nitriles to the aldehyde.[14] Regarding the proposed mechanism, DIBAL forms a Lewis acid-base adduct with the nitrile by formation of an N-Al bond. The hydride is then transferred to the carbon of the nitrile. Aqueous workup produce the desired aldehyde and ammonia.[15]

Electrochemical methods

Benzyl nitriles can also be reduced electrochemically.[16][17]

See also

References

  1. ↑ 1.0 1.1 1.2 Nishimura, Shigeo (2001). Handbook of Heterogeneous Catalytic Hydrogenation for Organic Synthesis (1st ed.). New York: Wiley-Interscience. pp. 254–277. ISBN 9780471396987. https://books.google.com/books?id=RjZRAAAAMAAJ&q=0471396982. 
  2. ↑ March, Jerry (1985), Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (3rd ed.), New York: Wiley, ISBN 0-471-85472-7 
  3. ↑ Karsten, Eller; Henkes, Erhard; Rossbacher, Roland; Höke, Hartmut (2000). "Amines, Aliphatic". Ullmann's Encyclopedia of Industrial Chemistry. doi:10.1002/14356007.a02_001. ISBN 3527306730. 
  4. ↑ Biggs, B. S.; Bishop, W. S. (1947). "Decamethylenediamine". Organic Syntheses 29: 18. doi:10.15227/orgsyn.027.0018. 
  5. ↑ Allen, C. F. H.; Wilson, C. V. (1947). "2,4-Diphenylpyrrole". Organic Syntheses 27: 33. doi:10.15227/orgsyn.027.0033. 
  6. ↑ Robinson, John C.; Snyder, H. R. (1943). "β-Phenylethylamine". Organic Syntheses 23: 71. doi:10.15227/orgsyn.023.0071. 
  7. ↑ Musser, Michael Tuttle (2000). "Adipic Acid". Ullmann's Encyclopedia of Industrial Chemistry. doi:10.1002/14356007.a01_269. ISBN 3527306730. 
  8. ↑ Barrault, J. (1997). "Synthesis of fatty amines. Selectivity control in presence of multifunctional catalysts". Catalysis Today 37 (2): 137–153. doi:10.1016/S0920-5861(97)00006-0. 
  9. ↑ Ookawa, Atsuhiro; Soai, Kenso (1986). "Mixed solvents containing methanol as useful reaction media for unique chemoselective reductions within lithium borohydride". The Journal of Organic Chemistry 51 (21): 4000–4005. doi:10.1021/jo00371a017. 
  10. ↑ Hutchins, R. O.; Maryanoff, B. E. (1973). "2-tert-Butyl-1,3-diaminoproane". Organic Syntheses 53: 21. doi:10.15227/orgsyn.053.0021. 
  11. ↑ Suter, C. M.; Moffett, Eugene W. (1934). "The Reduction of Aliphatic Cyanides and Oximes with Sodium and n-Butyl Alcohol". Journal of the American Chemical Society 56 (2): 487. doi:10.1021/ja01317a502. 
  12. ↑ van Es, T.; Staskun, B. (1971). "4-Formylbenzenesulfonamide". Organic Syntheses 51: 20. doi:10.15227/orgsyn.051.0020. 
  13. ↑ Smith, Michael; March, Jerry (October 2001). March's advanced organic chemistry : reactions, mechanisms, and structure. (5th ed.). New York: Wiley. ISBN 9780471585893. OCLC 43936853. 
  14. ↑ Carey, F. A.; Sundberg, R. J.; Advanced Organic Chemistry, Part B: Reactions and Synthesis
  15. ↑ Solomons, T W. G, Craig B. Fryhle, and S A. Snyder. Organic Chemistry. , 2014. Print.
  16. ↑ V. Krishnan; A. Muthukumaran; H. V. K. Udupa (1979). "The electroreduction of benzyl cyanide on iron and cobalt cathodes". Journal of Applied Electrochemistry 9 (5): 657–659. doi:10.1007/BF00610957. 
  17. ↑ V. Krishnan; A. Muthukumaran; H. V. K. Udupa (1983). Process for Electrochemical Preparation of beta phenylethylamine using cobalt black cathode. Calcutta: India Patent Office. http://cecri.csircentral.net/2305/1/151691.pdf. 



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