Chemistry:NL-201
NL-201 was an immunotherapy drug candidate that underwent a Phase 1 human clinical trial in cancer patients.[1] It is a de novo protein that was first computationally designed at the Institute of Protein Design (IPD), University of Washington.[2] In November 2022, Neoleukin Therapeutics announced it would discontinue the development of NL-201.[3]
History
The predecessor of NL-201, neoleukin-2/15, was first described and published on Nature magazine in January 2019.[2] The citizen science distributed computing project Rosetta@home, based at the University of Washington, contributed with "forward folding" experiments that helped validate protein designs of neoleukin-2/15, from which NL-201 was further developed by Neoleukin Therapeutics, a biopharmaceutical company that originated at the IPD.[4][5]
The Phase 1 human clinical trial began on May 5, 2021.[6]
In January 2022, Neoleukin Therapeutics announced a collaboration with Merck for a combination clinical trial of Merck's Pembrolizumab and Neoleukin's NL-201.[7]
In November 2022, Neoleukin Therapeutics announced it would discontinue the development of NL-201.[3]
References
- ↑ Neoleukin Therapeutics, Inc. (2021-05-25). A First-in-Human Phase 1 Study of NL-201 in Patients With Relapsed or Refractory Cancer. https://clinicaltrials.gov/ct2/show/study/NCT04659629.
- ↑ 2.0 2.1 Silva, Daniel-Adriano; Yu, Shawn; Ulge, Umut Y.; Spangler, Jamie B.; Jude, Kevin M.; Labão-Almeida, Carlos; Ali, Lestat R.; Quijano-Rubio, Alfredo et al. (2019-01-09). "De novo design of potent and selective mimics of IL-2 and IL-15" (in en). Nature 565 (7738): 186–191. doi:10.1038/s41586-018-0830-7. ISSN 1476-4687. PMID 30626941. Bibcode: 2019Natur.565..186S.
- ↑ 3.0 3.1 "Neoleukin Therapeutics Announces Third Quarter 2022 Financial Results and Corporate Update". 2022-11-14. https://investor.neoleukin.com/news-releases/news-release-details/neoleukin-therapeutics-announces-third-quarter-2022-financial.
- ↑ "Another publication in Nature describing the first de novo designed proteins with anti-cancer activity". https://boinc.bakerlab.org/rosetta/forum_thread.php?id=12926#90202.
- ↑ Therapeutics, Neoleukin (June 2020). "NL-201: A de novo CD25-independent combined IL-2 and IL-15 receptor agonistdesigned to selectively stimulate anti-tumor CD8+ effector T and NK cells". https://www.neoleukin.com/file.cfm/22/docs/FINAL_Walkey_et_al_AACR_2020_Poster_Abstract4518.pdf.
- ↑ "Neoleukin Therapeutics Announces Initiation of Phase 1 NL-201 Trial | Neoleukin Therapeutics, Inc." (in en). http://investor.neoleukin.com/news-releases/news-release-details/neoleukin-therapeutics-announces-initiation-phase-1-nl-201-trial.
- ↑ "Neoleukin Therapeutics Announces Clinical Collaboration with Merck to Evaluate NL-201 in Combination with KEYTRUDA® (pembrolizumab) | Neoleukin Therapeutics, Inc." (in en). http://investor.neoleukin.com/news-releases/news-release-details/neoleukin-therapeutics-announces-clinical-collaboration-merck.
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