Chemistry:Lumefantrine
From HandWiki
Short description: Group of enantiomers
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| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a609024 |
| Routes of administration | Oral |
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| Formula | C30H32Cl3NO |
| Molar mass | 528.94 g·mol−1 |
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| Melting point | 130 to 132 °C (266 to 270 °F) |
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Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with artemether. The term "co-artemether" is sometimes used to describe this combination.[1] Lumefantrine has a much longer half-life compared to artemether, and is therefore thought to clear any residual parasites that remain after combination treatment.[2]
Lumefantrine, along with pyronaridine and naphtoquine, were synthesized during the Chinese Project 523 antimalaria drug research effort initiated in 1967; these compounds are all used in combination antimalaria therapies.[3][4][5]
See also
- Artemether/lumefantrine
- Halofantrine
References
- ↑ "Successful co-artemether (artemether-lumefantrine) clearance of falciparum malaria in a patient with severe cholera in Mozambique". Travel Medicine and Infectious Disease 1 (3): 177–179. August 2003. doi:10.1016/j.tmaid.2003.09.002. PMID 17291911.
- ↑ "Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine". Clinical Pharmacokinetics 37 (2): 105–125. August 1999. doi:10.2165/00003088-199937020-00002. PMID 10496300.
- ↑ "Discovery, mechanisms of action and combination therapy of artemisinin". Expert Review of Anti-Infective Therapy 7 (8): 999–1013. October 2009. doi:10.1586/eri.09.68. PMID 19803708.
- ↑ "Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: a tolerability, safety, and preliminary efficacy study". Antimicrobial Agents and Chemotherapy 56 (5): 2465–2471. May 2012. doi:10.1128/AAC.06248-11. PMID 22330921.
- ↑ "Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial". PLOS Medicine 11 (12): e1001773. December 2014. doi:10.1371/journal.pmed.1001773. PMID 25549086.
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