Chemistry:LDN193189

From HandWiki
LDN193189
LDN193189 Structure.svg
Names
Preferred IUPAC name
4-{6-[4-(Piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}quinoline
Identifiers
3D model (JSmol)
UNII
Properties
C25H22N6
Molar mass 406.493 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Tracking categories (test):

LDN193189 is a chemical compound used in the study of bone morphogenetic protein signalling through the ALK2, ALK3 and ALK6 receptors.[1] It has been researched for the treatment of fibrodysplasia ossificans progressiva.[2]

See also


References

  1. Cuny GD, Yu PB, Laha JK, Xing X, Liu JF, Lai CS, Deng DY, Sachidanandan C, Bloch KD, Peterson RT. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4388-92. doi:10.1016/j.bmcl.2008.06.052 PMID 18621530
  2. Williams E, Bullock AN. Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2. Bone. 2018 Apr;109:251-258. doi:10.1016/j.bone.2017.09.004 PMID 28918311