Chemistry:JWH-372
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| Formula | C27H24F3NO |
| Molar mass | 435.490 g·mol−1 |
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JWH-372 (naphthalen-1-yl-[1-pentyl-5-[2-(trifluoromethyl)phenyl]pyrrol-3-yl]methanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as a potent and selective agonist of the CB2 receptor. JWH-372 binds approximately 9 times stronger to the CB2 receptor (Ki = 8.2 ± 0.2nM) than the CB1 receptor (Ki = 77 ± 2nM). The selectivity of JWH-372 for the CB2 receptor is likely due to the electron-withdrawing character of the trifluoromethyl group rather than steric effects, as the o-methyl compound JWH-370 was only mildly selective for the CB2 receptor (CB1 Ki = 5.6 ± 0.4nM, CB2 Ki = 4.0 ± 0.5nM). [1]
Legality
In the United States JWH-372 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-372.[2][3][4][5]
In Canada, JWH-372 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.[citation needed]
In the United Kingdom, JWH-372 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.[citation needed]
See also
- List of JWH cannabinoids
- Synthetic cannabinoid
References
- ↑ "1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors". Bioorganic & Medicinal Chemistry Letters 16 (20): 5432–5. October 2006. doi:10.1016/j.bmcl.2006.07.051. PMID 16889960.
- ↑ : Schedules of controlled substances
- ↑ "The 2020 Florida Statutes". http://www.leg.state.fl.us/Statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/Sections/0893.03.html.
- ↑ "Arizona Revised Statutes Title 13. Criminal Code § 13-3401". https://www.azleg.gov/ars/13/03401.htm.
- ↑ "California Code, Health and Safety Code - HSC § 11357.5". https://codes.findlaw.com/ca/health-and-safety-code/hsc-sect-11357-5.html.
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