Chemistry:Iberdomide
From HandWiki
Short description: Chemical compound
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| Formula | C25H27N3O5 |
| Molar mass | 449.507 g·mol−1 |
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Iberdomide is an experimental thalidomide analog[1] that works as an cereblon E3 ligase modulator; it has a higher binding affinity than lenalidomide or pomalidomide. It is developed by Bristol Myers Squibb for various cancers[2][3][4][5][6][7][8] and was also tested in people with lupus.[9]
References
- ↑ Gao, Shaobing; Wang, Shichao; Song, Yongping (December 2020). "Novel immunomodulatory drugs and neo-substrates". Biomarker Research 8 (1): 2. doi:10.1186/s40364-020-0182-y. PMID 31938543.
- ↑ Ye, Ying; Gaudy, Allison; Schafer, Peter; Thomas, Michael; Weiss, Daniel; Chen, Nianhang; Liu, Liangang; Xue, Yongjun et al. (May 2021). "First-in-Human, Single- and Multiple-Ascending-Dose Studies in Healthy Subjects to Assess Pharmacokinetics, Pharmacodynamics, and Safety/Tolerability of Iberdomide, a Novel Cereblon E3 Ligase Modulator". Clinical Pharmacology in Drug Development 10 (5): 471–485. doi:10.1002/cpdd.869. PMID 32969202.
- ↑ Bjorklund, Chad C.; Kang, Jian; Amatangelo, Michael; Polonskaia, Ann; Katz, Mark; Chiu, Hsiling; Couto, Suzana; Wang, Maria et al. (April 2020). "Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN" (in en). Leukemia 34 (4): 1197–1201. doi:10.1038/s41375-019-0620-8. ISSN 1476-5551. PMID 31719682.
- ↑ van de Donk, Niels W.C.J.; Popat, Rakesh; Larsen, Jeremy; Minnema, Monique C.; Jagannath, Sundar; Oriol, Albert; Zonder, Jeffrey; Richardson, Paul G. et al. (5 November 2020). "First Results of Iberdomide (IBER; CC-220) in Combination with Dexamethasone (DEX) and Daratumumab (DARA) or Bortezomib (BORT) in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)". Blood 136 (Supplement 1): 16–17. doi:10.1182/blood-2020-137743.
- ↑ Thieblemont, Catherine; Munoz, Javier; Tucci, Alessandra; Visco, Carlo; Cartron, Guillaume; Corradini, Paolo; Flinn, Ian W.; Gastinne, Thomas et al. (15 November 2022). "Iberdomide (CC-220) Monotherapy or in Combination with an Anti-CD20 Monoclonal Antibody As Effective Therapy in Patients with Relapsed/Refractory Lymphoma: Early Results from a Phase 1/2 Study". Blood 140 (Supplement 1): 569–572. doi:10.1182/blood-2022-162559.
- ↑ Lonial, Sagar; Amatangelo, Michael; Popat, Rakesh; Minnema, Monique C.; Zonder, Jeffrey A.; Larsen, Jeremy; Oriol Rocafiguera, Albert; Campagnaro, Erica L. et al. (13 November 2019). "Translational and Clinical Evidence of a Differentiated Profile for the Novel CELMoD, Iberdomide (CC-220)". Blood 134 (Supplement_1): 3119. doi:10.1182/blood-2019-124298.
- ↑ Amatangelo, Michael; Bjorklund, Chad C.; Kang, Jian; Polonskaia, Ann; Viswanatha, Sridevi; Thakurta, Anjan (29 November 2018). "Iberdomide (CC-220) Has Synergistic Anti-Tumor and Immunostimulatory Activity Against Multiple Myeloma in Combination with Both Bortezomib and Dexamethasone, or in Combination with Daratumumab in Vitro". Blood 132 (Supplement 1): 1935. doi:10.1182/blood-2018-99-113383.
- ↑ Lonial, Sagar; Popat, Rakesh; Hulin, Cyrille; Jagannath, Sundar; Oriol, Albert; Richardson, Paul G; Facon, Thierry; Weisel, Katja et al. (November 2022). "Iberdomide plus dexamethasone in heavily pretreated late-line relapsed or refractory multiple myeloma (CC-220-MM-001): a multicentre, multicohort, open-label, phase 1/2 trial". The Lancet Haematology 9 (11): e822–e832. doi:10.1016/S2352-3026(22)00290-3. PMID 36209764.
- ↑ Merrill, Joan T.; Werth, Victoria P.; Furie, Richard; van Vollenhoven, Ronald; Dörner, Thomas; Petronijevic, Milan; Velasco, Jorge; Majdan, Maria et al. (17 March 2022). "Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus". New England Journal of Medicine 386 (11): 1034–1045. doi:10.1056/NEJMoa2106535. PMID 35294813.
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