Chemistry:Fumarranol
From HandWiki
Short description: Chemical compound
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| Formula | C16H24O4 |
| Molar mass | 280.364 g·mol−1 |
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Fumarranol is a drug which acts as an inhibitor of the type 2 methionine aminopeptidase enzyme METAP2. It was derived by structural modification of the natural product fumagillin. It was originally developed as an anti-angiogenesis drug for the treatment of cancer,[1] but it was subsequently found to bind with high affinity to the METAP2 enzyme in malaria parasites and has been investigated as a potential treatment for malaria.[2][3]
See also
References
- ↑ "Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo". Journal of Medicinal Chemistry 49 (19): 5645–8. September 2006. doi:10.1021/jm060559v. PMID 16970390.
- ↑ "Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo". Chemistry & Biology 16 (2): 193–202. February 2009. doi:10.1016/j.chembiol.2009.01.006. PMID 19246010.
- ↑ "Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation". The FEBS Journal 284 (16): 2604–2628. August 2017. doi:10.1111/febs.14130. PMID 28599096.
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