Chemistry:Flavokavain A
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| Names | |
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| Preferred IUPAC name
2′-Hydroxy-4,4′,6′-trimethoxychalcone | |
| Other names
Flavokawain A
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| Identifiers | |
3D model (JSmol)
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| 2224776 | |
PubChem CID
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| UNII | |
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| Properties | |
| C18H18O5 | |
| Molar mass | 314.337 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
Tracking categories (test):
Flavokavain A is a flavokavain found in the kava plant.[1] It induces apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent apoptotic pathway.[2]
Flavokavains A and B enhance hepatotoxicity of paracetamol, underscoring a potentially serious interaction between paracetamol and kava.
See also
References
- ↑ Dharmaratne, H. Ranjith W.; N. P. Dhammika Nanayakkara; Ikhlas A. Khan (February 2002). "Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses". Phytochemistry 59 (4): 429–33. doi:10.1016/S0031-9422(01)00443-5. PMID 11830162.
- ↑ "Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.". Cancer Research 65 (8): 3479–86. April 2005. doi:10.1158/0008-5472.CAN-04-3803. PMID 15833884. https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S1_from_Flavokawain_A_a_Novel_Chalcone_from_Kava_Extract_Induces_Apoptosis_in_Bladder_Cancer_Cells_by_Involvement_of_Bax_Protein-Dependent_and_Mitochondria-Dependent_Apoptotic_Pathway_and_Suppresses_Tumor_Growth_in_Mice/22365111/1/files/39809379.pdf.
External links
- Flavokawain A at the United States National Library of Medicine
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