Chemistry:Estradiol monopropionate
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Short description: Chemical compound
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| Trade names | Acrofollin, Akrofollin, Follhormon |
| Other names | EP; Estradiol monopropionate; Estradiol propanoate; Estradiol 17β-propionate; Estradiol 17β-propanoate; Estra-1,3,5(10)-trien-3,17β-diol 17β-propionate |
| Routes of administration | Intramuscular injection |
| Drug class | Estrogen; Estrogen ester |
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| Chemical and physical data | |
| Formula | C21H28O3 |
| Molar mass | 328.452 g·mol−1 |
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Estradiol propionate (EP), also known as estradiol monopropionate or estradiol 17β-propionate and sold under the brand names Acrofollin, Akrofollin, and Follhormon, is an estrogen medication and estrogen ester which is no longer marketed.[1][2] It is the C17β propionate ester of estradiol.[1][2] EP was provided in an oil solution and was administered by intramuscular injection.[3][4][5][6] The medication was first marketed by 1938 or 1939.[7][8]
See also
References
- ↑ 1.0 1.1 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. p. 898. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=RA1-PA129.
- ↑ 2.0 2.1 Negwer, Martin (1994). Organic-chemical Drugs and Their Synonyms: (an International Survey). Akademie Verlag. p. 1967. ISBN 978-3-05-500156-7. https://books.google.com/books?id=ywltAAAAMAAJ. "Estra-1,3,5(10)-triene-3,17β-diol 17-propionate = 3,17β-Estradiol 17-monopropionate = (17β)-Estra-1,3,5(10)-triene-3,17-diol 17-propanoate (e) S Acrofollin, Akrofollin, Estradiol monopropionate, Follhormon "Saper", Ostradiolmonopropionat, Oestrolum propionicum U Estrogen"
- ↑ United States. Department of the Treasury (1942). Treasury Decisions Under the Customs, Internal Revenue, and Other Laws: Including the Decisions of the Board of General Appraisers and the Court of Customs Appeals. U.S. Government Printing Office. p. 135. https://books.google.com/books?id=nz3atjVOy5wC. "[...] T. D. 50714-C, covering akrofollin intramuscular oily solution of estrogenic hormone manufactured by Specific Pharmaceuticals, Inc., New York, N. Y., with the use of imported oestradiol-17-propionate crystals, [...]"
- ↑ "Apparent differences between the parenteral and intrauterine administration of estrogen substances". Gynaecologia 131 (1): 9–18. January 1951. doi:10.1159/000311707. PMID 14813560. "For the following two groups we have chosen estradiol propionate (Akrofollin) in a dose of 3 X 5 mg. In each instance we performed biopsic strip-abrasion on the third day after the termination of intrauterine, resp. intramuscular hormone administration.".
- ↑ "Alteration in the reactivity of hamster cheek pouch arterioles to prostaglandin E2 and noradrenaline during pregnancy or sex steroid treatment". Prostaglandins 26 (2): 165–73. August 1983. doi:10.1016/0090-6980(83)90085-0. PMID 6580678. "[...] they were treated each second day with 0.2 ml sunflower oil, 0.2 mg/lOO g bw of oestradiol propionate (Akrofollin, Richter), [...]".
- ↑ "Effect of sex hormones on copper, zinc, iron nutritional status and hepatic lipid peroxidation in rats". Die Nahrung 37 (1): 28–34. 1993. doi:10.1002/food.19930370106. PMID 8464456. "injected subcutaneously with oily solution of estradiol propionate (Acrofollin, Richter Gedeon)".
- ↑ Boletín oficial de la propiedad industrial. Carasa y Cía.. 1938. https://books.google.com/books?id=S7Gjg0GUIRUC. "Fecha del Fecha de la solicitud de la marca: Abril 13, 1938. Certificado de propiedad: Octubre 23, 1939. Nombre y domicilio del concesionario: Chinoin Fábrica de Productos Farmacéuticos y Química S. A., Ujpest, Hungría. AKROFOLLIN."
- ↑ "Die Wirkung natürlicher und künstlicher Brunststoffe im Tierversuch". Archiv für Gynäkologie 171 (2): 242–253. 1941. doi:10.1007/BF01714680. ISSN 0003-9128.
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