Chemistry:ENA-001
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Short description: Chemical compound
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| Routes of administration | IV |
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| Formula | C11H22N6O |
| Molar mass | 254.338 g·mol−1 |
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ENA-001 (formerly GAL-021)[1] is a drug related to almitrine which acts as a respiratory stimulant, with its mechanism of action primarily thought to involve blocking the BKCa potassium channel,[2] although secondary mechanisms may also be involved.[3] It was developed by Galleon Pharmaceuticals, and is being tested in clinical trials for potential uses in post-operative care,[4] as well as more generally to counteract the respiratory depression which can be a side effect of opioid analgesic drugs.[5][6][7]
See also
References
- ↑ "A Novel Agnostic Respiratory Stimulant as a Treatment for Apnea of Prematurity: A Proof-of-Concept Study". Cureus 14 (9): e28900. September 2022. doi:10.7759/cureus.28900. PMID 36237747.
- ↑ "GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers". British Journal of Anaesthesia 113 (5): 875–883. November 2014. doi:10.1093/bja/aeu182. PMID 24989775.
- ↑ "Comparison of the respiratory effects of GAL-021 in BK α subunit knockout (Slo1−/−) and wild-type mice". The FASEB Journal 26 (1 Supplement): 704.30. 2012. doi:10.1096/fasebj.26.1_supplement.704.30. http://www.fasebj.org/content/26/1_Supplement/704.30.abstract.
- ↑ "Respiratory stimulant drugs in the post-operative setting". Respiratory Physiology & Neurobiology 189 (2): 395–402. November 2013. doi:10.1016/j.resp.2013.06.010. PMID 23791825.
- ↑ "GAL-021, a novel respiratory stimulant, attenuates opioid–induced respiratory depression without compromising analgesia". The FASEB Journal 26 (1 Supplement): 704.28. 2012. doi:10.1096/fasebj.26.1_supplement.704.28. http://www.fasebj.org/content/26/1_Supplement/704.28.abstract.
- ↑ "Opioid-induced respiratory depression: reversal by non-opioid drugs". F1000Prime Reports 6: 79. 4 September 2014. doi:10.12703/P6-79. PMID 25343036.
- ↑ "Two studies on reversal of opioid-induced respiratory depression by BK-channel blocker GAL021 in human volunteers". Anesthesiology 121 (3): 459–468. September 2014. doi:10.1097/ALN.0000000000000367. PMID 25222672.
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