Chemistry:Comutagen
From HandWiki
A comutagen is a substance that is not a mutagen by itself, but in the presence of a mutagen, enhances mutagenic activity.[1] There are at least two manners by which this may occur; the comutagen may strengthen the mutagenic activity of mutagenic chemicals, or it can create a mutagenic response from nonmutagens.[2] Chemicals such as harmane and norharmane (present in tobacco tar) have been identified as comutagens.[3]
References
- ↑ National Research Council (US) Committee on Diet, Nutrition, and Cancer (1982). Diet, Nutrition, and Cancer. National Academic Press. https://www.ncbi.nlm.nih.gov/books/NBK216630/.
- ↑ Shamberger, R. (2012). Nutrition and Cancer. Springer US. p. 274. ISBN 978-1-4684-4670-8. https://books.google.com/books?id=JKvaBwAAQBAJ&pg=PA274. Retrieved 28 August 2018. "Modifiers of mutagenicity can be either comutagens or antimutagens. Comutagens are substances that enhance the mutagenic activity of a chemical even though it is not in itself mutagenic."
- ↑ De Serr, F.J.; Hollaender, A. (2013). Chemical Mutagens: Principles and Methods for Their Detection. Springer US. p. 52. ISBN 978-1-4613-3072-1. https://books.google.com/books?id=1QjaBwAAQBAJ&pg=PA52. Retrieved 28 August 2018. "Norharman and harman interfere with the metabolism of many mutagens/carcinogens, enhancing or depressing their mutagenicities. When norharman increases mutagenicity, its action can be called "comutagenic.""
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