Chemistry:Clitocine
From HandWiki
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| Preferred IUPAC name
(2R,3R,4S,5R)-2-[(6-Amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol | |
| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| Properties | |
| C9H13N5O6 | |
| Molar mass | 287.232 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
Clitocine is a mushroom nucleoside isolate with anticancer activity in vitro.[1][2][3]
References
- ↑ Ren, Gang; Zhao, Yun-Peng; Yang, Lu; Fu, Cheng-Xin (April 2008). "Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis". Cancer Letters 262 (2): 190–200. doi:10.1016/j.canlet.2007.12.013. PMID 18222036.
- ↑ Sun, Jianguo; Yeung, Chilam Au; Co, Ngai Na; Tsang, Tsun Yee; Yau, Esmond; Luo, Kewang; Wu, Ping; Wa, Judy Chan Yuet et al. (2012). "Clitocine reversal of P-glycoprotein associated multi-drug resistance through down-regulation of transcription factor NF-κB in R-HepG2 cell line". PLOS ONE 7 (8): e40720. doi:10.1371/journal.pone.0040720. PMID 22927901. Bibcode: 2012PLoSO...740720S.
- ↑ Sun, Jian-guo; Li, Hua; Li, Xia; Zeng, Xueli; Wu, Ping; Fung, Kwok-Pui; Liu, Fei-yan (May 2014). "Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo". Apoptosis 19 (5): 871–82. doi:10.1007/s10495-014-0969-0. PMID 24563182.
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