Chemistry:BRL-37344
From HandWiki
Short description: Chemical compound
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| Trade names | BRL-37344 |
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| Formula | C19H22ClNO4 |
| Molar mass | 363.8 g·mol−1 |
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BRL-37344 is a drug which acts as a selective agonist of the β3 adrenergic receptor,[1] which has been investigated for various biomedical research applications but never developed for clinical use.[2][3][4][5][6][7]
References
- ↑ "Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the alpha- and beta-subtypes". British Journal of Pharmacology 95 (3): 723–734. November 1988. doi:10.1111/j.1476-5381.1988.tb11698.x. PMID 2905184.
- ↑ "Effects of the beta3-adrenergic agonist BRL 37344 on endothelial nitric oxide synthase phosphorylation and force of contraction in human failing myocardium". Journal of Cardiac Failure 15 (1): 57–67. February 2009. doi:10.1016/j.cardfail.2008.08.006. PMID 19181295.
- ↑ "BRL37344, a β3-adrenergic receptor agonist, decreases nerve-evoked contractions in human detrusor smooth muscle isolated strips: role of BK channels". Urology 82 (3): 744.e1–744.e7. September 2013. doi:10.1016/j.urology.2013.05.027. PMID 23890664.
- ↑ "Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche". Nature Medicine 24 (6): 782–791. June 2018. doi:10.1038/s41591-018-0030-x. PMID 29736022.
- ↑ "β3-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway". Biochemical and Biophysical Research Communications 503 (1): 146–151. September 2018. doi:10.1016/j.bbrc.2018.05.200. PMID 29859189.
- ↑ "Effects of β3-adrenergic receptor stimulation on the resting holding current of medial prefrontal cortex pyramidal neurons in young rats". Neuroscience Letters 698: 192–197. April 2019. doi:10.1016/j.neulet.2019.01.022. PMID 30641111.
- ↑ "Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery". npj Regenerative Medicine 5: 3. 2020. doi:10.1038/s41536-020-0088-1. PMID 32133156.
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